SIRT2 and CDC14B

Number of citations of the paper that reports this interaction (PMID 12697818)
79

Data Source:
HPRD (in vitro, in vivo)

		SIRT2	CDC14B
Gene Name		sirtuin 2	cell division cycle 14B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Chromatin Silencing Complex Chromosome Nuclear Heterochromatin Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Plasma Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Chromatin Binding NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Beta-tubulin Binding NAD+ Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Silencing Chromatin Silencing At Telomere Transcription, DNA-templated Protein ADP-ribosylation Protein Deacetylation Autophagy Mitotic Nuclear Division Regulation Of Exit From Mitosis Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Phosphatidylinositol 3-kinase Signaling Gene Silencing Histone Deacetylation Substantia Nigra Development Myelination In Peripheral Nervous System Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Protein Kinase B Signaling Cellular Lipid Catabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Caloric Restriction Negative Regulation Of Oligodendrocyte Progenitor Proliferation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response To Bacterium Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	DNA Repair Protein Dephosphorylation G2 DNA Damage Checkpoint Peptidyl-tyrosine Dephosphorylation Activation Of Anaphase-promoting Complex Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CDC14B CDC20 EP300 FZR1 HDAC6 HIST1H3A HOXA10 KAT2A KAT2B SP140 TUBA4A TUBB XPO1	3 interactors: SIRT2 SKP2 TP53
Entrez ID		22933	8555
HPRD ID		10377	04615
Ensembl ID		ENSG00000068903	ENSG00000081377
Uniprot IDs		Q8IXJ6	O60729
PDB IDs		1J8F 3ZGO 3ZGV	1OHC 1OHD 1OHE
Enriched GO Terms of Interacting Partners?		Activation Of Anaphase-promoting Complex Activity Cell Cycle Organelle Organization Cell Cycle Process N-terminal Peptidyl-lysine Acetylation Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Transferase Activity Chromosome Organization Peptidyl-lysine Modification Positive Regulation Of Ligase Activity Chromatin Modification Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Mitotic Cell Cycle Process Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Positive Regulation Of Gluconeogenesis Negative Regulation Of Cellular Metabolic Process Histone Modification Protein Acetylation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Cycle N-terminal Protein Amino Acid Modification Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Response To Stress Chromatin Remodeling Positive Regulation Of Glucose Metabolic Process G2 DNA Damage Checkpoint Viral Process Regulation Of Protein Ubiquitination Histone H3-K9 Modification Cell Cycle Checkpoint Regulation Of Meiosis Histone H3 Acetylation Regulation Of Gluconeogenesis Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition	Cellular Response To Extracellular Stimulus Necroptotic Process Negative Regulation Of Autophagy Negative Regulation Of Reactive Oxygen Species Metabolic Process Programmed Necrotic Cell Death Response To Extracellular Stimulus Necrotic Cell Death Negative Regulation Of Neural Precursor Cell Proliferation Mitotic Cell Cycle Process Mitotic Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Neural Precursor Cell Proliferation Regulation Of Autophagy Regulation Of Cell Cycle Cellular Response To Oxygen Levels Cell Cycle Process Cellular Response To Starvation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Defense Response To Bacterium Cellular Response To Caloric Restriction Negative Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Cell Cycle Cellular Response To Oxidative Stress Negative Regulation Of Macromitophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Cellular Response To Cell-matrix Adhesion Oligodendrocyte Apoptotic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Chromatin Silencing At Telomere Negative Regulation Of Helicase Activity Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To External Stimulus Negative Regulation Of Cell Development Regulation Of Protein Complex Assembly Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Defense Response To Bacterium Ripoptosome Assembly Positive Regulation Of Thymocyte Apoptotic Process
Tagcloud ?		3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype	checkpoints chk1 damage dead dual effector error exogenous export facilitate fibrillarin gst immunoprecipitation instability integrity interplay localized maintenance nucleolar nucleolus phosphatase phosphorylate pull radiation serine shuttling sirna threonine ucn
Tagcloud (Difference) ?		3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype	checkpoints chk1 damage dead dual effector error exogenous export facilitate fibrillarin gst immunoprecipitation instability integrity interplay localized maintenance nucleolar nucleolus phosphatase phosphorylate pull radiation serine shuttling sirna threonine ucn
Tagcloud (Intersection) ?