CARD8 and CARD18

Number of citations of the paper that reports this interaction (PMID 11821383)
31

Data Source:
HPRD (in vivo, in vitro)

		CARD8	CARD18
Gene Name		caspase recruitment domain family, member 8	caspase recruitment domain family, member 18
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NLRP3 Inflammasome Complex	Cellular_component
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion	Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG NLRP2 NLRP3	2 interactors: CARD17 CARD8
Entrez ID		22900	59082
HPRD ID		16425	16099
Ensembl ID		ENSG00000105483	ENSG00000255501
Uniprot IDs		E5RFV9 I6L9C6 Q9Y2G2	P57730
PDB IDs		4IKM	1DGN
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidase Activity Positive Regulation Of Interleukin-1 Production Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Beta Production Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Production Zymogen Activation Apoptotic Process Programmed Cell Death Interleukin-1 Beta Production Cell Death Death Regulation Of Cytokine Secretion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Protein Secretion Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Other Organism Positive Regulation Of Catalytic Activity Protein Processing Response To Biotic Stimulus Innate Immune Response Regulation Of Metabolic Process	Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Apoptotic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Protein Secretion Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Intersection) ?