CARD18 and CARD17

Number of citations of the paper that reports this interaction (PMID 15383541)
19

Data Source:
HPRD (in vitro, in vivo)

		CARD18	CARD17
Gene Name		caspase recruitment domain family, member 18	caspase recruitment domain family, member 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity	Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process	Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CARD17 CARD8	3 interactors: CARD16 CARD18 CASP1
Entrez ID		59082	440068
HPRD ID		16099	17149
Ensembl ID		ENSG00000255501	ENSG00000255221
Uniprot IDs		P57730	Q5XLA6
PDB IDs		1DGN
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Apoptotic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Protein Secretion Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity	Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Mitochondrial Depolarization Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Interleukin-1 Alpha Secretion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Pyroptosis Positive Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Catalytic Activity Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Catalytic Activity Response To ATP Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Metabolic Process Membrane Hyperpolarization Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Interleukin-1 Beta Production Cellular Response To Mechanical Stimulus Defense Response Execution Phase Of Apoptosis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Autophagy Membrane Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Cytokine Production Positive Regulation Of Peptidase Activity
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