CARD8 and NLRP2

Number of citations of the paper that reports this interaction (PMID 15030775)
246

Data Source:
HPRD (in vivo)

		CARD8	NLRP2
Gene Name		caspase recruitment domain family, member 8	NLR family, pyrin domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NLRP3 Inflammasome Complex	Cytoplasm
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity	Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion	Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG NLRP2 NLRP3	4 interactors: APP CARD8 FAF1 PYDC2
Entrez ID		22900	55655
HPRD ID		16425	14805
Ensembl ID		ENSG00000105483	ENSG00000022556
Uniprot IDs		E5RFV9 I6L9C6 Q9Y2G2	J3KN39 Q9NX02
PDB IDs		4IKM
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidase Activity Positive Regulation Of Interleukin-1 Production Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Beta Production Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Production Zymogen Activation Apoptotic Process Programmed Cell Death Interleukin-1 Beta Production Cell Death Death Regulation Of Cytokine Secretion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Protein Secretion Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Other Organism Positive Regulation Of Catalytic Activity Protein Processing Response To Biotic Stimulus Innate Immune Response Regulation Of Metabolic Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Collateral Sprouting In Absence Of Injury Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Endopeptidase Activity Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neuron Remodeling Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Copper Ion Homeostasis Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Sequestering Of Protein Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Interleukin-1 Beta Production Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Mating Behavior
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp1 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Intersection) ?		nlrp1