FCGR3B and APCS

Number of citations of the paper that reports this interaction (PMID 11359830)
26

Data Source:
HPRD (in vitro)

		FCGR3B	APCS
Gene Name		Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	amyloid P component, serum
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	IgG Binding	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding
	Biological Process	Immune Response	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways			Amyloids
Drugs		Cetuximab Etanercept Intravenous Immunoglobulin Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab	Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	C-reactive protein ( 22939635)
Protein-Protein Interactions		2 interactors: APCS IGHG1	17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		2215	325
HPRD ID		09951	00101
Ensembl ID		ENSG00000162747	ENSG00000132703
Uniprot IDs		M9MML6 O75015	P02743
PDB IDs		1E4J 1E4K 1FNL 1T83 1T89	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Monocyte Differentiation Negative Regulation Of Glycoprotein Metabolic Process Chaperone-mediated Protein Complex Assembly Regulation Of Monocyte Differentiation Negative Regulation Of Acute Inflammatory Response Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Interaction With Symbiont Immune Response Regulation Of Immune System Process Defense Response Acute-phase Response Negative Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Negative Regulation Of Viral Process Acute Inflammatory Response Negative Regulation Of Myeloid Cell Differentiation Immune System Process Negative Regulation Of Inflammatory Response Regulation Of Myeloid Leukocyte Differentiation Complement Activation, Classical Pathway Regulation Of Wound Healing Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Viral Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Protein Activation Cascade Regulation Of Myeloid Cell Differentiation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Locomotion Response To Stress Phagocytosis Leukocyte Mediated Immunity Fc Receptor Signaling Pathway Adaptive Immune Response Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Folding Cellular Protein Complex Assembly	Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway
Tagcloud ?		advantages applicability carry cloned cnas cnvs comparable competitive competitors copy cost erbb2 invaluable issues limitations mrcpcr nci numbers panel paralog prt reproducibility requirement responsiveness shorter solve utilizing variations	aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Difference) ?		advantages applicability carry cloned cnas cnvs comparable competitive competitors copy cost erbb2 invaluable issues limitations mrcpcr nci numbers panel paralog prt reproducibility requirement responsiveness shorter solve utilizing variations	aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Intersection) ?