APCS and FCGR1A

Number of citations of the paper that reports this interaction (PMID 11359830)
26

Data Source:
HPRD (in vitro)

		APCS	FCGR1A
Gene Name		amyloid P component, serum	Fc fragment of IgG, high affinity Ia, receptor (CD64)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding	Receptor Signaling Protein Activity Protein Binding IgG Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Phagocytosis, Engulfment Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Interferon-gamma-mediated Signaling Pathway
Pathways		Amyloids	Interferon gamma signaling Interferon Signaling Cross-presentation of soluble exogenous antigens (endosomes) Role of phospholipids in phagocytosis Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs		Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE	Cetuximab Etanercept Intravenous Immunoglobulin Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer Methyl aminolevulinate
Diseases
GWAS		C-reactive protein ( 22939635)
Protein-Protein Interactions		17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	10 interactors: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK
Entrez ID		325	2209
HPRD ID		00101	00904
Ensembl ID		ENSG00000132703	ENSG00000150337
Uniprot IDs		P02743	P12314
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	3RJD
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway	Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Inflammatory Response Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Other Organism Response To Biotic Stimulus Exocytosis Vesicle-mediated Transport Innate Immune Response Regulation Of Superoxide Anion Generation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stimulus Regulation Of Cell Activation Response To Bacterium Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Secretion By Cell Defense Response To Bacterium Platelet Activation Positive Regulation Of Tissue Remodeling Regulation Of Platelet Activation Wound Healing Regulation Of Cell Adhesion Secretion Endocytosis Peptidyl-tyrosine Autophosphorylation Acute-phase Response Regulation Of Cell Adhesion Mediated By Integrin Response To Fungus Response To Wounding Leukocyte Degranulation Response To Organic Substance Regulation Of T Cell Activation Regulated Secretory Pathway Regulation Of Phagocytosis Negative Regulation Of Wound Healing Defense Response To Gram-positive Bacterium Regulation Of Tissue Remodeling
Tagcloud ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected
Tagcloud (Difference) ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected
Tagcloud (Intersection) ?