F13A1 and UFD1L

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		F13A1	UFD1L
Gene Name		coagulation factor XIII, A1 polypeptide	ubiquitin fusion degradation 1 like (yeast)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen Blood Microparticle	Nucleus Cytosol
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Metal Ion Binding	Ubiquitin-specific Protease Activity Receptor Binding Protein Binding Protein Complex Binding
	Biological Process	Platelet Degranulation Blood Coagulation Peptide Cross-linking Platelet Activation	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		1,2-Propanediol N-Acetyl-Serine
Diseases
GWAS		End-stage coagulation ( 23381943) MRI atrophy measures ( 21116278)
Protein-Protein Interactions		13 interactors: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1L	19 interactors: A2M AMFR ANAPC2 F13A1 GZMK IGHM MASP1 NEDD8 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBXN6 VCP
Entrez ID		2162	7353
HPRD ID		00604	06778
Ensembl ID		ENSG00000124491	ENSG00000070010
Uniprot IDs		P00488	Q541A5 Q92890
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK	2YUJ
Enriched GO Terms of Interacting Partners?		Hemostasis Regulation Of Body Fluid Levels Platelet Activation Blood Coagulation Wound Healing Response To Wounding Platelet Degranulation Regulation Of Cell Morphogenesis Regulation Of Cellular Component Organization Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Acute-phase Response Regulation Of Cell Shape Positive Regulation Of Phosphorylation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Protein Complex Assembly Acute Inflammatory Response Negative Regulation Of Fibrinolysis Response To Stress Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Blood Coagulation Regulation Of Fibrinolysis Response To Metal Ion Exocytosis Response To Calcium Ion Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Defense Response Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Endothelial Cell Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Differentiation ERBB Signaling Pathway Positive Regulation Of Collagen Metabolic Process Response To Inorganic Substance Cell-matrix Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fibrinolysis Secretion By Cell	Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Complement Activation ER-nucleus Signaling Pathway Response To Growth Factor Regulation Of Fibroblast Apoptotic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Blood Coagulation Hemostasis Regulation Of Complement Activation Cellular Response To Organic Substance Response To Organic Substance Platelet Activation Regulation Of Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Neurotrophin TRK Receptor Signaling Pathway Vesicle-mediated Transport Neurotrophin Signaling Pathway Regulation Of Humoral Immune Response Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Body Fluid Levels Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z
Tagcloud (Difference) ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z
Tagcloud (Intersection) ?