UFD1L and ANAPC2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UFD1L	ANAPC2
Gene Name		ubiquitin fusion degradation 1 like (yeast)	anaphase promoting complex subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ubiquitin-specific Protease Activity Receptor Binding Protein Binding Protein Complex Binding	Ubiquitin Protein Ligase Binding
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: A2M AMFR ANAPC2 F13A1 GZMK IGHM MASP1 NEDD8 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBXN6 VCP	13 interactors: ANAPC11 ANAPC5 ANAPC7 CDC20 CDC26 CDC27 FBXO5 FZR1 MAD2L1 SMAD2 UBE2C UBE2S UFD1L
Entrez ID		7353	29882
HPRD ID		06778	07367
Ensembl ID		ENSG00000070010	ENSG00000176248
Uniprot IDs		Q541A5 Q92890	B4DGH7 Q9UJX6
PDB IDs		2YUJ
Enriched GO Terms of Interacting Partners?		Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Complement Activation ER-nucleus Signaling Pathway Response To Growth Factor Regulation Of Fibroblast Apoptotic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Blood Coagulation Hemostasis Regulation Of Complement Activation Cellular Response To Organic Substance Response To Organic Substance Platelet Activation Regulation Of Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Neurotrophin TRK Receptor Signaling Pathway Vesicle-mediated Transport Neurotrophin Signaling Pathway Regulation Of Humoral Immune Response Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Body Fluid Levels Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Protein K11-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cellular Protein Catabolic Process Spindle Assembly Checkpoint Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Segregation Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Mitotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Cellular Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Chromosome Organization Cellular Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process
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