F13A1 and FGA

Number of citations of the paper that reports this interaction (PMID 10956659)
9

Data Source:
HPRD (in vitro)

		F13A1	FGA
Gene Name		coagulation factor XIII, A1 polypeptide	fibrinogen alpha chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Metal Ion Binding	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding
	Biological Process	Platelet Degranulation Blood Coagulation Peptide Cross-linking Platelet Activation	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Amyloids Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		1,2-Propanediol N-Acetyl-Serine	Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Alpha-D-Mannose
Diseases
GWAS		End-stage coagulation ( 23381943) MRI atrophy measures ( 21116278)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494)
Protein-Protein Interactions		13 interactors: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1L	15 interactors: CDH5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 NID1 PLAT PRRC2A SERPINA5 SERPINF2 THBS1 UBC
Entrez ID		2162	2243
HPRD ID		00604	00619
Ensembl ID		ENSG00000124491	ENSG00000171560
Uniprot IDs		P00488	P02671
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK	1BBR 1DM4 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27
Enriched GO Terms of Interacting Partners?		Hemostasis Regulation Of Body Fluid Levels Platelet Activation Blood Coagulation Wound Healing Response To Wounding Platelet Degranulation Regulation Of Cell Morphogenesis Regulation Of Cellular Component Organization Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Acute-phase Response Regulation Of Cell Shape Positive Regulation Of Phosphorylation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Protein Complex Assembly Acute Inflammatory Response Negative Regulation Of Fibrinolysis Response To Stress Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Blood Coagulation Regulation Of Fibrinolysis Response To Metal Ion Exocytosis Response To Calcium Ion Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Defense Response Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Endothelial Cell Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Differentiation ERBB Signaling Pathway Positive Regulation Of Collagen Metabolic Process Response To Inorganic Substance Cell-matrix Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fibrinolysis Secretion By Cell	Platelet Degranulation Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Exocytosis Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Fibrinolysis Secretion By Cell Extracellular Matrix Organization Extracellular Structure Organization Secretion Fibrinolysis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell-substrate Adhesion Platelet Aggregation Response To Stress Positive Regulation Of Coagulation Regulation Of Wound Healing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell-matrix Adhesion Negative Regulation Of Coagulation Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Negative Regulation Of Wound Healing Regulation Of Protein Processing Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Establishment Of Localization In Cell Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cell Adhesion Regulation Of Endothelial Cell Apoptotic Process Cellular Localization Negative Regulation Of Endothelial Cell Chemotaxis Cell Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z	antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Difference) ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z	antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Intersection) ?