ETS2 and SPI1

Number of citations of the paper that reports this interaction (PMID 9681824)
14

Data Source:
BioGRID (pull down)

		ETS2	SPI1
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog 2	Spi-1 proto-oncogene
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromatin
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways		Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 21079520)
Protein-Protein Interactions		20 interactors: CDK10 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 RFWD2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		2114	6688
HPRD ID		01263	01305
Ensembl ID		ENSG00000157557	ENSG00000066336
Uniprot IDs		P15036	P17947
PDB IDs		4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Positive Regulation By Host Of Viral Transcription Response To Steroid Hormone Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Signaling Gland Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Response To Lipid Biosynthetic Process Leukocyte Differentiation Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Myeloid Cell Differentiation Response To Organic Cyclic Compound Tissue Development	Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process
Tagcloud ?		3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Difference) ?		3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Intersection) ?