ETS2 and POU5F1

Number of citations of the paper that reports this interaction (PMID 11689681)
16

Data Source:
HPRD (in vivo, in vitro)

		ETS2	POU5F1
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog 2	POU class 5 homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Endodermal Cell Fate Specification Blastocyst Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Maintenance Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Negative Regulation Of Gene Silencing By MiRNA Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Methylation-dependent Chromatin Silencing
Pathways		Cellular Senescence Oncogene Induced Senescence	Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 21079520)	Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 21801394)
Protein-Protein Interactions		20 interactors: CDK10 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 RFWD2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	14 interactors: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5 WWP2
Entrez ID		2114	5460
HPRD ID		01263	01252
Ensembl ID		ENSG00000157557	ENSG00000204531
Uniprot IDs		P15036	D2IYK3 M1S623 Q01860
PDB IDs		4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Positive Regulation By Host Of Viral Transcription Response To Steroid Hormone Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Signaling Gland Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Response To Lipid Biosynthetic Process Leukocyte Differentiation Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Myeloid Cell Differentiation Response To Organic Cyclic Compound Tissue Development	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Sex Differentiation Regulation Of Cell Death System Development RNA Metabolic Process Nitrogen Compound Metabolic Process Developmental Process Involved In Reproduction Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Cellular Macromolecule Biosynthetic Process Male Sex Differentiation Positive Regulation Of Cell Proliferation Multicellular Organismal Development Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Proliferation
Tagcloud ?		3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Difference) ?		3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Intersection) ?