GTF2E2 and SUPT16H

Number of citations of the paper that reports this interaction (PMID 10792464)
5

Data Source:
HPRD (in vitro, two hybrid)

		GTF2E2	SUPT16H
Gene Name		general transcription factor IIE, polypeptide 2, beta 34kDa	suppressor of Ty 16 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIE Complex Cytoplasm	Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding Protein Binding Poly(A) RNA Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		23 interactors: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KLF5 MCC MDM2 MNAT1 NUP62 SND1 SUPT16H TBP XPA	10 interactors: GTF2E2 H2AFX H3F3A HIST1H2AI MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2
Entrez ID		2961	11198
HPRD ID		01800	16088
Ensembl ID		ENSG00000197265	ENSG00000092201
Uniprot IDs		P29084	Q9Y5B9
PDB IDs		1D8J 1D8K
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase I Promoter Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping RNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Biosynthetic Process DNA Catabolic Process Regulation Of Metabolic Process MRNA Processing Negative Regulation Of Gene Expression	DNA Conformation Change Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Heterocycle Metabolic Process DNA Replication Initiation Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nuclear Speck Organization DNA Duplex Unwinding DNA Geometric Change Cell Cycle Process DNA-dependent DNA Replication Nucleosome Assembly Nucleus Organization Regulation Of Growth Rate Protein Poly-ADP-ribosylation Chromatin Assembly Nucleosome Organization Cell Cycle Double-strand Break Repair Chromatin Assembly Or Disassembly G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecular Complex Assembly Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Process DNA Packaging Cellular Metabolic Process Mitotic Cell Cycle DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription Regulatory Region DNA Binding DNA-templated Transcription, Initiation Protein Autoprocessing DNA Unwinding Involved In DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Methylation On Cytosine DNA Replication Positive Regulation Of SMAD Protein Import Into Nucleus Chromatin Silencing At RDNA Regulation Of SMAD Protein Import Into Nucleus Gene Expression Macrophage Differentiation RNA Splicing Positive Regulation Of Viral Genome Replication
Tagcloud ?		avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1	altering breaks checkpoint chemo conjunction cooperate disassembly dsb dsbs dynamic facilitates fact gammah2ax h2ax h2b h2bub1 h3k56ac homolog mechanistic monoubiquitination phenocopied proper pursuing rational repair rnf40 strand timely ty
Tagcloud (Difference) ?		avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1	altering breaks checkpoint chemo conjunction cooperate disassembly dsb dsbs dynamic facilitates fact gammah2ax h2ax h2b h2bub1 h3k56ac homolog monoubiquitination phenocopied proper pursuing rational repair rnf40 strand timely ty
Tagcloud (Intersection) ?		mechanistic