EPHA7 and EFNA4

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vitro)

		EPHA7	EFNA4
Gene Name		EPH receptor A7	ephrin-A4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane
	Molecular Function	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade	Cell-cell Signaling Axon Guidance Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267	8 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 MAP2K4
Entrez ID		2045	1945
HPRD ID		03721	03224
Ensembl ID		ENSG00000135333	ENSG00000243364
Uniprot IDs		Q15375	P52798
PDB IDs		2REI 3DKO 3H8M 3NRU
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis	Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Peptidyl-amino Acid Modification Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cell Development Response To External Stimulus Neuron Development Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Phosphate-containing Compound Metabolic Process Neurogenesis Fasciculation Of Motor Neuron Axon Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cell Differentiation Fasciculation Of Sensory Neuron Axon Nervous System Development Regulation Of MAPK Cascade Regulation Of Catalytic Activity Anatomical Structure Morphogenesis System Development Regulation Of Rho GTPase Activity Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Rho Protein Signal Transduction Multicellular Organismal Development Anatomical Structure Development Regulation Of Signaling Signal Transduction Developmental Process Protein Metabolic Process Signaling
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Intersection) ?