EFNA4 and EPHA2

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vitro, in vivo)

		EFNA4	EPHA2
Gene Name		ephrin-A4	EPH receptor A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Cell-cell Signaling Axon Guidance Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs			Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS		Prostate cancer ( 23535732)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		8 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 MAP2K4	30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID		1945	1969
HPRD ID		03224	01494
Ensembl ID		ENSG00000243364	ENSG00000142627
Uniprot IDs		P52798	P29317
PDB IDs			1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Peptidyl-amino Acid Modification Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cell Development Response To External Stimulus Neuron Development Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Phosphate-containing Compound Metabolic Process Neurogenesis Fasciculation Of Motor Neuron Axon Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cell Differentiation Fasciculation Of Sensory Neuron Axon Nervous System Development Regulation Of MAPK Cascade Regulation Of Catalytic Activity Anatomical Structure Morphogenesis System Development Regulation Of Rho GTPase Activity Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Rho Protein Signal Transduction Multicellular Organismal Development Anatomical Structure Development Regulation Of Signaling Signal Transduction Developmental Process Protein Metabolic Process Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels
Tagcloud ?			abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Difference) ?			abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Intersection) ?