EPHA5 and EFNA1

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vivo)

		EPHA5	EFNA1
Gene Name		EPH receptor A5	ephrin-A1
Image
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Axon Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	Receptor Binding Protein Binding Ephrin Receptor Binding
	Biological Process	Axon Guidance Peptidyl-tyrosine Phosphorylation CAMP-mediated Signaling Hippocampus Development Regulation Of Rac GTPase Activity Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		HIV-1 viral setpoint ( 22174851)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 NEDD4	14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6
Entrez ID		2044	1942
HPRD ID		02474	01858
Ensembl ID		ENSG00000145242	ENSG00000169242
Uniprot IDs		B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4	P20827
PDB IDs		2R2P 4ET7	3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Projection Development Neuron Development Axon Guidance Neuron Differentiation Cell Projection Organization Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Generation Of Neurons Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Cell Morphogenesis Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Cell Differentiation Response To External Stimulus Cell-cell Signaling System Development Osteoclast Differentiation Multicellular Organismal Development Anatomical Structure Development Bone Remodeling Signal Transduction Regulation Of Dendrite Morphogenesis Developmental Process Signaling Cell Communication Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Dendrite Development Tissue Remodeling Myeloid Leukocyte Differentiation Cellular Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Dendritic Spine Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Mesenchyme Development Regulation Of Peptidyl-tyrosine Phosphorylation	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development
Tagcloud ?		aurka aurkb bioinformatics cdkn2a copy custom describing flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses map2k4 multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		aurka aurkb bioinformatics cdkn2a copy custom describing flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses map2k4 multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?