EFNA1 and EPHA4

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vitro)

		EFNA1	EPHA4
Gene Name		ephrin-A1	EPH receptor A4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Cell Junction Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Dendritic Spine Perikaryon Axon Terminus Axonal Growth Cone Postsynaptic Membrane
	Molecular Function	Receptor Binding Protein Binding Ephrin Receptor Binding	Protein Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis	Cell Adhesion Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Regulation Of Rac GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Dendritic Spine Morphogenesis Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)	Brain imaging ( 20100581) Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6	15 interactors: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC
Entrez ID		1942	2043
HPRD ID		01858	03719
Ensembl ID		ENSG00000169242	ENSG00000116106
Uniprot IDs		P20827	E9PG71 P54764 Q58F15
PDB IDs		3CZU 3HEI 3MBW	2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Axon Guidance Neuron Development Peptidyl-tyrosine Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Generation Of Neurons Neurogenesis Cell Surface Receptor Signaling Pathway Locomotion Anatomical Structure Morphogenesis Cell Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction System Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To External Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Cell-cell Signaling Response To Fibroblast Growth Factor Peptidyl-amino Acid Modification Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Multicellular Organismal Development Anatomical Structure Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Phosphorylation
Tagcloud ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Difference) ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Intersection) ?