BGN and WISP1

Number of citations of the paper that reports this interaction (PMID 11598131)
23

Data Source:
HPRD (in vitro)

		BGN	WISP1
Gene Name		biglycan	WNT1 inducible signaling pathway protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Glycosaminoglycan Binding Extracellular Matrix Binding	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Blood Vessel Remodeling Carbohydrate Metabolic Process Biological_process Pathogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Wnt Signaling Pathway Negative Regulation Of Cell Death
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Graves' disease ( 23612905) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		16 interactors: APOB APP BMP4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HDL3 JPH3 MFAP2 PLA2G1B TGFB1 TNF WISP1	2 interactors: BGN DCN
Entrez ID		633	8840
HPRD ID		02359	16019
Ensembl ID		ENSG00000182492
Uniprot IDs		B4DNL4 P21810 Q8NAB7	O95388
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Locomotion Anatomical Structure Morphogenesis Multicellular Organismal Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Response To External Stimulus Organ Morphogenesis Protein Localization To Nucleus Collagen Catabolic Process Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Leukocyte Migration System Development Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Myoblast Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Bone Morphogenesis Chemotaxis Multicellular Organismal Development Response To Growth Factor Immune System Process Anatomical Structure Development Cell Morphogenesis Organ Development Salivary Gland Morphogenesis Endochondral Ossification Gland Morphogenesis Regulation Of Myoblast Differentiation Salivary Gland Development Negative Regulation Of Muscle Cell Differentiation Cellular Response To Acid Chemical Cellular Response To Lipid Cellular Response To Transforming Growth Factor Beta Stimulus Blood Coagulation Hemostasis Developmental Process Exocrine System Development Response To Transforming Growth Factor Beta Platelet Activation Cartilage Development Common-partner SMAD Protein Phosphorylation Cell Migration Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cardiovascular System Development	Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Peptide Cross-linking Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Glycosaminoglycan Metabolic Process Pathogenesis Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Monocarboxylic Acid Metabolic Process Peptidyl-amino Acid Modification Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Organic Acid Metabolic Process Blood Vessel Remodeling Catabolic Process Extracellular Matrix Disassembly Tissue Remodeling Small Molecule Metabolic Process Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Placenta Development Response To Mechanical Stimulus Cellular Protein Modification Process Muscle Organ Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Kidney Development Striated Muscle Tissue Development Response To Lipopolysaccharide Aging Renal System Development Response To Molecule Of Bacterial Origin Muscle Tissue Development Urogenital System Development Cellular Protein Metabolic Process
Tagcloud ?		bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna	began calories cancerous carcinogen catenin chow continued corresponded den diethylnitrosamine ethanol etoh foci gsk3beta hepatocyte initiating insult livers mmp7 multiplicity pair pf promotion retinol stores tumorigenic wnt2 wnt7a wnts
Tagcloud (Difference) ?		bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna	began calories cancerous carcinogen catenin chow continued corresponded den diethylnitrosamine ethanol etoh foci gsk3beta hepatocyte initiating insult livers mmp7 multiplicity pair pf promotion retinol stores tumorigenic wnt2 wnt7a wnts
Tagcloud (Intersection) ?