CELA1 and SERPINA1

Number of citations of the paper that reports this interaction (PMID 1079736)
2

Data Source:
HPRD (in vitro, in vivo)

		CELA1	SERPINA1
Gene Name		chymotrypsin-like elastase family, member 1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Golgi Apparatus Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Glycoprotein Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Pancreas Morphogenesis	Response To Hypoxia Platelet Degranulation Acute-phase Response Blood Coagulation Response To Lead Ion Negative Regulation Of Endopeptidase Activity Platelet Activation Response To Estradiol Response To Lipopolysaccharide Response To Methanol Response To Triglyceride Response To Cytokine Response To Chromate Negative Regulation Of Serine-type Endopeptidase Activity
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs			2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol
Diseases
GWAS		Obesity-related traits ( 23251661)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Metabolite levels ( 22916037)
Protein-Protein Interactions		6 interactors: A2M CSN2 LPA PI3 SERPINA1 SERPINA3	26 interactors: ADAMTS4 ATP5C1 CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GSDMB KLK13 KLK3 KLK5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1
Entrez ID		1990	5265
HPRD ID		00553	02463
Ensembl ID		ENSG00000139610	ENSG00000197249
Uniprot IDs		Q9UNI1	E9KL23 P01009
PDB IDs			1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 7API 8API 9API
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Acute-phase Response Platelet Degranulation Acute Inflammatory Response Response To Methanol Regulation Of Body Fluid Levels Secretion Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Platelet Activation Regulation Of Metabolic Process Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Cullin Deneddylation Protein Deneddylation Exocytosis Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Complement Activation Inflammatory Response Blood Coagulation Hemostasis Epithelial Structure Maintenance Copulation Secretion By Cell Response To Lead Ion Regulation Of Complement Activation Wound Healing Negative Regulation Of Innate Immune Response Cell Activation Response To Wounding Regulation Of Humoral Immune Response Mating	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Protein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Cobalamin Metabolic Process Metabolic Process Response To Stress Vitamin Metabolic Process Digestion Killing By Host Of Symbiont Cells Defense Response Defense Response To Bacterium Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Protein Processing Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Fungus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Beta-amyloid Clearance Response To Bacterium Small Molecule Metabolic Process Response To External Stimulus Negative Regulation Of Growth Negative Regulation Of Locomotion Response To Stimulus Factor XII Activation Nephrogenic Mesenchyme Morphogenesis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Defense Response To Gram-positive Bacterium Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Acute Inflammatory Response Phototransduction, Visible Light Wound Healing
Tagcloud ?			abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Difference) ?			abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Intersection) ?