EDA and DOLK

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EDA	DOLK
Gene Name		ectodysplasin A	dolichol kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding	Dolichol Kinase Activity
	Biological Process	Immune Response Cell-matrix Adhesion Signal Transduction Ectoderm Development Gene Expression Cell Differentiation Positive Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Phosphorylation Protein N-linked Glycosylation Via Asparagine Dolichyl Monophosphate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514)
Protein-Protein Interactions		15 interactors: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A	1 interactors: EDA
Entrez ID		1896	22845
HPRD ID		02347	15525
Ensembl ID		ENSG00000158813	ENSG00000175283
Uniprot IDs		Q92838	Q9UPQ8
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-15 Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cytotoxic T Cell Differentiation Negative Regulation Of Calcium-transporting ATPase Activity TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Dolichyl Monophosphate Biosynthetic Process Negative Regulation Of Hydrolase Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Nerve Growth Factor Production Negative Regulation Of Calcium Ion Binding Regulation Of The Force Of Heart Contraction By Cardiac Conduction Protein N-linked Glycosylation Via Asparagine Cell Death Death Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Membrane Raft Polarization Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Receptor Catabolic Process Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein N-linked Glycosylation Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Nerve Growth Factor Processing G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Membrane Raft Localization Dolichyl Diphosphate Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Transforming Growth Factor Beta Production Ectodermal Cell Differentiation Regulation Of JNK Cascade Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Salivary Gland Cavitation Regulation Of Stress-activated MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of ATPase Activity Regulation Of Relaxation Of Muscle Vesicle Fusion With Golgi Apparatus Regulation Of Cardiac Muscle Cell Membrane Potential Post-translational Protein Modification Transport	Trachea Gland Development Salivary Gland Cavitation Hair Follicle Placode Formation Positive Regulation Of NF-kappaB Import Into Nucleus Ectoderm Development Trachea Development Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of NF-kappaB Import Into Nucleus Salivary Gland Morphogenesis Salivary Gland Development Exocrine System Development Regulation Of Transcription Factor Import Into Nucleus Hair Follicle Development Positive Regulation Of Protein Import Into Nucleus Hair Cycle Process Hair Cycle Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Pigmentation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Odontogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Intracellular Protein Transport Gland Morphogenesis Tube Formation Regulation Of Protein Import Into Nucleus Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell-substrate Adhesion Regulation Of Canonical Wnt Signaling Pathway Skin Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Epidermis Development Respiratory System Development Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Transport Tube Morphogenesis Regulation Of Intracellular Transport Gland Development Regulation Of Protein Transport
Tagcloud ?		amplitudes asymmetry atypical comparison conductance contralateral depend discrepancy disinhibition electrodermal former frontal hemisphere idea left lesion motor neurophysiological phasic rejected right scl scls seem showing sweating tonic unrelated weakness
Tagcloud (Difference) ?		amplitudes asymmetry atypical comparison conductance contralateral depend discrepancy disinhibition electrodermal former frontal hemisphere idea left lesion motor neurophysiological phasic rejected right scl scls seem showing sweating tonic unrelated weakness
Tagcloud (Intersection) ?