E2F5 and RBL2

Number of citations of the paper that reports this interaction (PMID 11756542)
16

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		E2F5	RBL2
Gene Name		E2F transcription factor 5, p130-binding	retinoblastoma-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Gene Expression Cell Projection Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Cyclin D associated events in G1 G1 Phase G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CREBBP EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1	42 interactors: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 LBX1 LDHC MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 SUV420H2 TAF1 TOP1 UBTF USP4 XBP1
Entrez ID		1875	5934
HPRD ID		02983	01576
Ensembl ID		ENSG00000133740	ENSG00000103479
Uniprot IDs		Q15329	Q08999 Q8NE70
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Viral Process N-terminal Peptidyl-lysine Acetylation Cell Cycle DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Notch Signaling Pathway RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromatin Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Modification Chromatin Organization Regulation Of Cellular Response To Heat Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Organic Substance Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Response To Hypoxia Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process	Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Gene Expression Cell Cycle Process Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cell Division Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Process DNA-templated Transcription, Initiation Cellular Metabolic Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Chromosome Organization Cellular Response To Stress Regulation Of Protein Kinase Activity
Tagcloud ?		angiogenic anticarcinogenic c33a cascades collapse dr5 e6 e7 extrinsic fadd fasl fitc flavonoid fluorescein hela iodide isothiocyanate luteolin multidrug observing oncogenes papilloma performing prb propidium trail versa vice xl	arginine bcl3 casp10 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		angiogenic anticarcinogenic c33a cascades collapse dr5 e6 e7 extrinsic fadd fasl fitc flavonoid fluorescein hela iodide isothiocyanate luteolin multidrug observing oncogenes papilloma performing prb propidium trail versa vice xl	arginine bcl3 casp10 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?