DTNA and DMD

Number of citations of the paper that reports this interaction (PMID 9356463)
33

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DTNA	DMD
Gene Name		dystrobrevin, alpha	dystrophin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Sarcolemma Protein Complex Synapse	Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Cell Junction Filopodium Filopodium Membrane Sarcolemma Costamere Protein Complex Membrane Raft Postsynaptic Membrane
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Synaptic Transmission Neuromuscular Synaptic Transmission	Regulation Of Heart Rate Muscle Organ Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Muscle Filament Sliding Extracellular Matrix Organization Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Peptide Biosynthetic Process Cellular Protein Complex Assembly Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Striated Muscle Contraction Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		14 interactors: ACTA1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 SYNC SYNM UTRN	27 interactors: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 KCNJ12 KRT19 KRT8 MAP3K5 PGM5 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 UTRN
Entrez ID		1837	1756
HPRD ID		03141	02303
Ensembl ID		ENSG00000134769	ENSG00000198947
Uniprot IDs		A8K541 B7Z3X3 M0QYX6 Q9Y4J8	A1L0U9 A7E212 P11532 Q16484 Q4G0X0
PDB IDs		2E5R	1DXX 1EG3 1EG4 3UUN
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Myotube Cell Development Actin-myosin Filament Sliding Muscle Filament Sliding Cardiac Muscle Cell Action Potential Intermediate Filament-based Process Actin-mediated Cell Contraction Muscle Fiber Development Positive Regulation Of Cell-matrix Adhesion Muscle Organ Development Myotube Differentiation Actin Filament-based Movement Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Establishment Of Glial Blood-brain Barrier Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Muscle Structure Development Skeletal Muscle Tissue Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Skeletal Muscle Organ Development System Development Regulation Of Muscle Contraction Striated Muscle Cell Development Synaptic Transmission Regulation Of Dopamine Receptor Signaling Pathway Skeletal Muscle Thin Filament Assembly Olfactory Nerve Development Muscle Cell Development Regulation Of Skeletal Muscle Contraction Actin Filament-based Process Skeletal Myofibril Assembly Neurotransmitter Receptor Metabolic Process Regulation Of Cell-substrate Adhesion Platelet Dense Granule Organization	Muscle Contraction Muscle System Process Muscle Cell Development Myofibril Assembly Actomyosin Structure Organization Organelle Assembly Cellular Component Assembly Muscle Structure Development Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Cell Development Skeletal Myofibril Assembly Synaptic Vesicle Priming Striated Muscle Cell Differentiation Organ Development Cytoskeleton Organization Organelle Organization Muscle Organ Development Positive Regulation Of Proteolysis Cell Development System Development Positive Regulation Of Peptidase Activity Cell Differentiation Involved In Embryonic Placenta Development Actin-myosin Filament Sliding Muscle Filament Sliding Movement Of Cell Or Subcellular Component Regulation Of Sodium Ion Transmembrane Transport Microtubule-based Process Actin-mediated Cell Contraction Programmed Necrotic Cell Death Nerve Maturation Regulation Of Vasoconstriction By Circulating Norepinephrine Necrotic Cell Death Multicellular Organismal Development Sarcomere Organization Neuromuscular Junction Development Synaptic Vesicle Exocytosis Anatomical Structure Development Actin Filament-based Movement Cell-cell Signaling Heart Contraction Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Calcium-dependent Cell-matrix Adhesion Regulation Of Sodium Ion Transport Anatomical Structure Morphogenesis Viral Process Apoptotic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death
Tagcloud ?			2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Difference) ?			2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Intersection) ?