JAG1 and MLLT4

Number of citations of the paper that reports this interaction (PMID 9707552)
37

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		JAG1	MLLT4
Gene Name		jagged 1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Part Of Cell	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Growth Factor Activity	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding
	Biological Process	Angiogenesis Cell Fate Determination Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet T Cell Mediated Immunity Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Notch Signaling Pathway Notch Receptor Processing Nervous System Development Hemopoiesis Keratinocyte Differentiation Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Proliferation Auditory Receptor Cell Differentiation Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Notch Signaling Involved In Heart Development Endocardial Cushion Cell Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance Negative Regulation Of Stem Cell Differentiation	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Bone mineral density ( 20096396 22504420) Cardiac hypertrophy ( 21348951) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)	Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		7 interactors: MFNG MLLT4 NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1	37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		182	4301
HPRD ID		03562	01164
Ensembl ID		ENSG00000101384	ENSG00000130396
Uniprot IDs		P78504 Q99740	P55196
PDB IDs		2KB9 2VJ2	1T2M 1XZ9 2AIN 2EXG
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Blood Vessel Development Vasculature Development Negative Regulation Of Endothelial Cell Chemotaxis Angiogenesis Cardiovascular System Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Blood Vessel Morphogenesis Protein O-linked Fucosylation Interleukin-4 Production Pattern Specification Process Heart Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Blood Vessel Endothelial Cell Migration Glomerulus Vasculature Development Negative Regulation Of Chemotaxis Heart Morphogenesis DNA-templated Transcription, Initiation Cardiac Atrium Morphogenesis Developmental Process Tissue Development Inflammatory Response To Antigenic Stimulus Fucosylation Cytokine Secretion Heart Valve Morphogenesis Negative Regulation Of Endothelial Cell Migration Heart Valve Development Positive Regulation Of BMP Signaling Pathway Endocardial Cushion Development Cell Fate Commitment Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Cell-substrate Adhesion Cardiac Septum Morphogenesis Sprouting Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Glomerulus Development Morphogenesis Of An Epithelial Sheet Inflammatory Response Anatomical Structure Morphogenesis Endothelial Cell Differentiation Neuron Fate Commitment Positive Regulation Of Signal Transduction Negative Regulation Of Angiogenesis Cardiac Septum Development Regulation Of BMP Signaling Pathway	Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning
Tagcloud ?		activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase ptprk responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase ptprk responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Intersection) ?