JAG1 and NOTCH2

Number of citations of the paper that reports this interaction (PMID 10551863)
49

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		JAG1	NOTCH2
Gene Name		jagged 1	notch 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Part Of Cell	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Growth Factor Activity	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
	Biological Process	Angiogenesis Cell Fate Determination Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet T Cell Mediated Immunity Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Notch Signaling Pathway Notch Receptor Processing Nervous System Development Hemopoiesis Keratinocyte Differentiation Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Proliferation Auditory Receptor Cell Differentiation Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Notch Signaling Involved In Heart Development Endocardial Cushion Cell Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance Negative Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Bone mineral density ( 20096396 22504420) Cardiac hypertrophy ( 21348951) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)	Type 2 diabetes ( 18372903)
Protein-Protein Interactions		7 interactors: MFNG MLLT4 NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1	18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1
Entrez ID		182	4853
HPRD ID		03562	02606
Ensembl ID		ENSG00000101384	ENSG00000134250
Uniprot IDs		P78504 Q99740	Q04721 Q6IQ50 Q9UFD5
PDB IDs		2KB9 2VJ2	2OO4
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Blood Vessel Development Vasculature Development Negative Regulation Of Endothelial Cell Chemotaxis Angiogenesis Cardiovascular System Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Blood Vessel Morphogenesis Protein O-linked Fucosylation Interleukin-4 Production Pattern Specification Process Heart Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Blood Vessel Endothelial Cell Migration Glomerulus Vasculature Development Negative Regulation Of Chemotaxis Heart Morphogenesis DNA-templated Transcription, Initiation Cardiac Atrium Morphogenesis Developmental Process Tissue Development Inflammatory Response To Antigenic Stimulus Fucosylation Cytokine Secretion Heart Valve Morphogenesis Negative Regulation Of Endothelial Cell Migration Heart Valve Development Positive Regulation Of BMP Signaling Pathway Endocardial Cushion Development Cell Fate Commitment Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Cell-substrate Adhesion Cardiac Septum Morphogenesis Sprouting Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Glomerulus Development Morphogenesis Of An Epithelial Sheet Inflammatory Response Anatomical Structure Morphogenesis Endothelial Cell Differentiation Neuron Fate Commitment Positive Regulation Of Signal Transduction Negative Regulation Of Angiogenesis Cardiac Septum Development Regulation Of BMP Signaling Pathway	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis
Tagcloud ?		activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase ptprk responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Difference) ?		activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jagged kappa keratinocyte keratinocytes ligand limiting phosphatase ptprk responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Intersection) ?		notch notch1