MLLT4 and RIT2

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (two hybrid)

		MLLT4	RIT2
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Ras-like without CAAX 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell	Nucleus Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding	GTPase Activity Calmodulin Binding GTP Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA) ( 23319000)	Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-Protein Interactions		37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		4301	6014
HPRD ID		01164	15253
Ensembl ID		ENSG00000130396	ENSG00000152214
Uniprot IDs		P55196	Q99578
PDB IDs		1T2M 1XZ9 2AIN 2EXG
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning	Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Intersection) ?