ACAN and LUM

Number of citations of the paper that reports this interaction (PMID 15505028)
7

Data Source:
HPRD (in vitro)

		ACAN	LUM
Gene Name		aggrecan	lumican
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Carbohydrate Metabolic Process Visual Perception Pathogenesis Response To Organic Cyclic Compound Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development Response To Growth Factor
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	5 interactors: ACAN COL1A2 GNAQ MMP14 TRA2B
Entrez ID		176	4060
HPRD ID		01123	02793
Ensembl ID		ENSG00000157766
Uniprot IDs		E7ENV9 E7EX88	P51884
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Extracellular Matrix Disassembly Skeletal System Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Anatomical Structure Morphogenesis Platelet Activation Organ Morphogenesis Organ Development Skeletal System Morphogenesis Astrocyte Cell Migration Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Chondrocyte Proliferation Keratan Sulfate Catabolic Process Protein Heterotrimerization Regulation Of Melanocyte Differentiation Blood Coagulation Hemostasis Maternal Behavior Craniofacial Suture Morphogenesis Endothelial Cell Proliferation Catabolic Process System Development Negative Regulation Of Focal Adhesion Assembly Blood Vessel Development Regulation Of Catenin Import Into Nucleus Vasculature Development Regulation Of Developmental Pigmentation Keratan Sulfate Biosynthetic Process Cartilage Condensation Regulation Of Body Fluid Levels Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Keratan Sulfate Metabolic Process Wound Healing Neuron Maturation Multicellular Organismal Development Embryonic Morphogenesis Chondrocyte Development Protein Trimerization Positive Regulation Of RNA Splicing Dopamine Receptor Signaling Pathway Anatomical Structure Development Cell Activation
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Intersection) ?