ACAN and ADAMTS5

Number of citations of the paper that reports this interaction (PMID 11854269)
12

Data Source:
HPRD (in vivo)

		ACAN	ADAMTS5
Gene Name		aggrecan	ADAM metallopeptidase with thrombospondin type 1 motif, 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Protein O-linked Glycosylation Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Protein O-linked Fucosylation Defense Response To Bacterium Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	2 interactors: ACAN MMP13
Entrez ID		176	11096
HPRD ID		01123	05420
Ensembl ID		ENSG00000157766	ENSG00000154736
Uniprot IDs		E7ENV9 E7EX88	Q9UNA0
PDB IDs			2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Extracellular Matrix Disassembly Cartilage Development Connective Tissue Development Skeletal System Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Keratan Sulfate Catabolic Process Growth Plate Cartilage Development Organ Morphogenesis Keratan Sulfate Biosynthetic Process Cartilage Condensation Keratan Sulfate Metabolic Process Endochondral Bone Growth Chondrocyte Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Bone Mineralization Proteolysis Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Collagen Fibril Organization Collagen Catabolic Process Tissue Development Catabolic Process Biomineral Tissue Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endochondral Bone Morphogenesis Chondrocyte Differentiation Multicellular Organismal Metabolic Process Glycosaminoglycan Biosynthetic Process Organ Growth Proteoglycan Metabolic Process Bone Morphogenesis Anatomical Structure Morphogenesis Developmental Growth Involved In Morphogenesis Glycosaminoglycan Metabolic Process Organ Development Pathogenesis Bone Development Developmental Growth Ossification Sulfur Compound Metabolic Process System Development
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	1ss aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	1ss aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled
Tagcloud (Intersection) ?