LUM and MMP14

Number of citations of the paper that reports this interaction (PMID 15466200)
20

Data Source:
HPRD (in vivo)

		LUM	MMP14
Gene Name		lumican	matrix metallopeptidase 14 (membrane-inserted)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Carbohydrate Metabolic Process Visual Perception Pathogenesis Response To Organic Cyclic Compound Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development Response To Growth Factor	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		5 interactors: ACAN COL1A2 GNAQ MMP14 TRA2B	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		4060	4323
HPRD ID		02793	02856
Ensembl ID			ENSG00000157227
Uniprot IDs		P51884	P50281
PDB IDs			1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Skeletal System Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Anatomical Structure Morphogenesis Platelet Activation Organ Morphogenesis Organ Development Skeletal System Morphogenesis Astrocyte Cell Migration Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Chondrocyte Proliferation Keratan Sulfate Catabolic Process Protein Heterotrimerization Regulation Of Melanocyte Differentiation Blood Coagulation Hemostasis Maternal Behavior Craniofacial Suture Morphogenesis Endothelial Cell Proliferation Catabolic Process System Development Negative Regulation Of Focal Adhesion Assembly Blood Vessel Development Regulation Of Catenin Import Into Nucleus Vasculature Development Regulation Of Developmental Pigmentation Keratan Sulfate Biosynthetic Process Cartilage Condensation Regulation Of Body Fluid Levels Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Keratan Sulfate Metabolic Process Wound Healing Neuron Maturation Multicellular Organismal Development Embryonic Morphogenesis Chondrocyte Development Protein Trimerization Positive Regulation Of RNA Splicing Dopamine Receptor Signaling Pathway Anatomical Structure Development Cell Activation	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?		clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?