DLX5 and SOX10

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid, in vitro)

		DLX5	SOX10
Gene Name		distal-less homeobox 5	SRY (sex determining region Y)-box 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Cytoplasm	Nucleus Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Regulatory Region DNA Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Transcription, DNA-templated Nervous System Development Axon Guidance Cell Proliferation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	In Utero Embryonic Development Neural Crest Cell Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gliogenesis Melanocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN	28 interactors: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		1749	6663
HPRD ID		02492	03752
Ensembl ID		ENSG00000105880	ENSG00000100146
Uniprot IDs		P56178 Q53Y73	B4DV62 P56693
PDB IDs		2DJN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Mesenchymal Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Mesenchyme Development Activation Of Meiosis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process BMP Signaling Pathway Involved In Heart Development Connective Tissue Development Stem Cell Development Skeletal System Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Differentiation Nail Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Gliogenesis Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Enteric Nervous System Development Odontogenesis Organ Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Meiotic Nuclear Division Endocardial Cushion Formation RNA Metabolic Process Embryo Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process System Development Macromolecule Biosynthetic Process Protein Sumoylation Embryonic Morphogenesis Anatomical Structure Development Embryonic Organ Development Embryo Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Cellular Nitrogen Compound Metabolic Process Pattern Specification Process Embryonic Organ Morphogenesis Organ Morphogenesis Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Gland Development
Tagcloud ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Difference) ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specified surprisingly th thalamic thalamus tracing whereby	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally stationary temporally unexpected
Tagcloud (Intersection) ?		specification