DLX5 and SOX8

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid)

		DLX5	SOX8
Gene Name		distal-less homeobox 5	SRY (sex determining region Y)-box 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Cytoplasm	Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Regulatory Region DNA Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Transcription, DNA-templated Nervous System Development Axon Guidance Cell Proliferation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		9 interactors: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN	18 interactors: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		1749	30812
HPRD ID		02492	16175
Ensembl ID		ENSG00000105880	ENSG00000005513
Uniprot IDs		P56178 Q53Y73	P57073
PDB IDs		2DJN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Mesenchymal Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Mesenchyme Development Activation Of Meiosis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process BMP Signaling Pathway Involved In Heart Development Connective Tissue Development Stem Cell Development Skeletal System Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Differentiation Nail Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Gliogenesis Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Enteric Nervous System Development Odontogenesis Organ Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Meiotic Nuclear Division Endocardial Cushion Formation RNA Metabolic Process Embryo Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Cell Differentiation Tissue Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Liver Development Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Embryonic Organ Development Positive Regulation By Host Of Viral Transcription Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Heart Development Endoderm Development
Tagcloud ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Difference) ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Intersection) ?