DHFR and AMFR

Number of citations of the paper that reports this interaction (PMID 24810856)
0

Data Source:
BioGRID (enzymatic study)

		DHFR	AMFR
Gene Name		dihydrofolate reductase	autocrine motility factor receptor, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytosol	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Neuronal Cell Body Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity Drug Binding NADP Binding	Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycine Biosynthetic Process One-carbon Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nucleotide Biosynthetic Process Response To Methotrexate Small Molecule Metabolic Process Nitric Oxide Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Nitric-oxide Synthase Activity Oxidation-reduction Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Aging Learning Or Memory ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Protein Oligomerization
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of nitric oxide G1/S Transition G1/S-Specific Transcription Metabolism of folate and pterines eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Mitotic G1-G1/S phases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency E2F mediated regulation of DNA replication Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Cell Cycle, Mitotic Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		NADH Pyrimethamine Trimethoprim Methotrexate Pemetrexed Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2\',5\'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3\',4\',5\'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 2\'-Monophosphoadenosine 5\'-Diphosphoribose 6-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3-D]Pyrimidine-2,4-Diamine Biopterin 2,4-Diamino-6-[N-(3\',5\'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4\'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3\',5\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2\',6\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AMFR ASGR1 FKBP1A GKAP1 HSPD1 MDM2 THBS1 TOMM20 TP53 UBC	26 interactors: BAG6 CRMP1 CYP2E1 CYP3A4 DERL1 DHFR GPI HERPUD1 HTT KPNB1 SOD1 SYVN1 TOM1L1 TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UFD1L VCP
Entrez ID		1719	267
HPRD ID		00519	09130
Ensembl ID		ENSG00000228716	ENSG00000159461
Uniprot IDs		B0YJ76 B4DDD2 P00374	Q9UKV5
PDB IDs		1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4M6J 4M6K 4M6L	2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Hypoxia Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Negative Regulation Of Catalytic Activity Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Organic Substance Negative Regulation Of Hydrolase Activity Leukocyte Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Unfolded Protein Regulation Of Cell Cycle G1/S Phase Transition Apoptotic Process Negative Regulation Of Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Magnesium Ion Programmed Cell Death DNA Damage Checkpoint Protein Refolding Protein Complex Assembly Cell Death Death Mitotic Cell Cycle Checkpoint	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Cellular Metabolic Process Cellular Response To Stress Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Response To Stress Protein K63-linked Ubiquitination Response To Organic Substance ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Response To Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Apoptotic Process Toll-like Receptor Signaling Pathway Programmed Cell Death Cell Death Death Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Retrograde Protein Transport, ER To Cytosol Response To Unfolded Protein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Monoterpenoid Metabolic Process
Tagcloud ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated	anchoring catalyzed dnas e3 eris facilitating herpes hsv insig1 interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers
Tagcloud (Difference) ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated	anchoring catalyzed dnas e3 eris facilitating herpes hsv insig1 interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers
Tagcloud (Intersection) ?