DHFR and TOMM20

Number of citations of the paper that reports this interaction (PMID 9119086)
5

Data Source:
HPRD (in vitro)

		DHFR	TOMM20
Gene Name		dihydrofolate reductase	translocase of outer mitochondrial membrane 20 homolog (yeast)
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytosol	Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane ER-mitochondrion Membrane Contact Site
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity Drug Binding NADP Binding	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Unfolded Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycine Biosynthetic Process One-carbon Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nucleotide Biosynthetic Process Response To Methotrexate Small Molecule Metabolic Process Nitric Oxide Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Nitric-oxide Synthase Activity Oxidation-reduction Process	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Protein Transmembrane Transport
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of nitric oxide G1/S Transition G1/S-Specific Transcription Metabolism of folate and pterines eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Mitotic G1-G1/S phases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency E2F mediated regulation of DNA replication Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Cell Cycle, Mitotic Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Mitochondrial protein import
Drugs		NADH Pyrimethamine Trimethoprim Methotrexate Pemetrexed Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2\',5\'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3\',4\',5\'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 2\'-Monophosphoadenosine 5\'-Diphosphoribose 6-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3-D]Pyrimidine-2,4-Diamine Biopterin 2,4-Diamino-6-[N-(3\',5\'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4\'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3\',5\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2\',6\'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS			Cholesterol, total ( 20686565) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: AMFR ASGR1 FKBP1A GKAP1 HSPD1 MDM2 THBS1 TOMM20 TP53 UBC	17 interactors: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 DHFR FEZ1 HAP1 KIAA1377 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1
Entrez ID		1719	9804
HPRD ID		00519	03507
Ensembl ID		ENSG00000228716	ENSG00000173726
Uniprot IDs		B0YJ76 B4DDD2 P00374	Q15388
PDB IDs		1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4M6J 4M6K 4M6L	4APO
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Hypoxia Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Negative Regulation Of Catalytic Activity Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Organic Substance Negative Regulation Of Hydrolase Activity Leukocyte Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Unfolded Protein Regulation Of Cell Cycle G1/S Phase Transition Apoptotic Process Negative Regulation Of Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Magnesium Ion Programmed Cell Death DNA Damage Checkpoint Protein Refolding Protein Complex Assembly Cell Death Death Mitotic Cell Cycle Checkpoint	Mitochondrial Transport Cellular Localization Regulation Of Protein Stability Establishment Of Localization In Cell Developmental Process Anatomical Structure Development Posttranscriptional Regulation Of Gene Expression Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Intracellular Transport Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Learning Mitochondrion Organization Regulation Of Mitotic Cell Cycle Cell Differentiation Cell Cycle Single-organism Behavior Negative Regulation Of Autophagy Response To Organic Cyclic Compound Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Behavioral Fear Response Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Fear Response Protein Localization To Organelle Response To Drug Axon Regeneration Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Anion Homeostasis Organ Development Regulation Of Cell Cycle Phase Transition Neuron Projection Regeneration Behavior Organelle Organization Ornithine Catabolic Process Negative Regulation Of Cellular PH Reduction Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cell Adhesion Molecule Production Learning Or Memory Protein Transmembrane Transport System Development Mitochondrial Membrane Organization
Tagcloud ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated
Tagcloud (Difference) ?		attains becomes charged combine crossed dehydrofolate evolutionarily export import imported inner inserted intermembrane lengths moieties oxa1p pairwise peptidase polytopic postulate poxa1p preproteins presequence segments sorting stop stretches tm translocated
Tagcloud (Intersection) ?