AMFR and CYP3A4

Number of citations of the paper that reports this interaction (PMID 19103148)
15

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study)

		AMFR	CYP3A4
Gene Name		autocrine motility factor receptor, E3 ubiquitin protein ligase	cytochrome P450, family 3, subfamily A, polypeptide 4
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Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Neuronal Cell Body Protein Complex Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Taurochenodeoxycholate 6alpha-hydroxylase Activity Caffeine Oxidase Activity Albendazole Monooxygenase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Vitamin D 24-hydroxylase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Aging Learning Or Memory ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Protein Oligomerization	Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		26 interactors: BAG6 CRMP1 CYP2E1 CYP3A4 DERL1 DHFR GPI HERPUD1 HTT KPNB1 SOD1 SYVN1 TOM1L1 TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UFD1L VCP	9 interactors: AMFR CYB5A GK POR PRKACA PRKCA STUB1 UBC UGT2B7
Entrez ID		267	1576
HPRD ID		09130	00484
Ensembl ID		ENSG00000159461
Uniprot IDs		Q9UKV5	P08684 Q6GRK0
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O	1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Cellular Metabolic Process Cellular Response To Stress Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Response To Stress Protein K63-linked Ubiquitination Response To Organic Substance ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Response To Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Apoptotic Process Toll-like Receptor Signaling Pathway Programmed Cell Death Cell Death Death Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Retrograde Protein Transport, ER To Cytosol Response To Unfolded Protein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Monoterpenoid Metabolic Process	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Response To Organic Substance Monosaccharide Metabolic Process Small Molecule Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Organic Substance Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Catabolic Process Energy Reserve Metabolic Process Carbohydrate Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Polyubiquitination Negative Regulation Of Adenylate Cyclase Activity Flavonoid Metabolic Process Negative Regulation Of Lyase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Response To Growth Factor Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Neurotrophin TRK Receptor Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Neurotrophin Signaling Pathway Inactivation Of MAPK Activity Regulation Of Hormone Metabolic Process Regulation Of Proteolysis Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		anchoring catalyzed dnas e3 eris facilitating herpes hsv insig1 interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Difference) ?		anchoring catalyzed dnas e3 eris facilitating herpes hsv insig1 interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Intersection) ?