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AP1B1 and ARRB2
Number of citations of the paper that reports this interaction (PMID
10097102
)
113
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
AP1B1
ARRB2
Gene Name
adaptor-related protein complex 1, beta 1 subunit
arrestin, beta 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Cytosol
Clathrin Adaptor Complex
Cytoplasmic Vesicle Membrane
Clathrin-coated Vesicle Membrane
Trans-Golgi Network Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
Transporter Activity
Protein Binding
Protein Transporter Activity
Protein Kinase Binding
G-protein Coupled Receptor Binding
Receptor Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Type 1 Angiotensin Receptor Binding
D1 Dopamine Receptor Binding
Follicle-stimulating Hormone Receptor Binding
Type 2A Serotonin Receptor Binding
Protein Complex Binding
Protein Complex Scaffold
Protein Kinase B Binding
Mitogen-activated Protein Kinase Binding
14-3-3 Protein Binding
Biological Process
Intracellular Protein Transport
Post-Golgi Vesicle-mediated Transport
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Defense Response To Virus By Virus
Membrane Organization
G-protein Coupled Receptor Internalization
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin
Positive Regulation Of Receptor Internalization
Transcription From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Brain Development
Blood Coagulation
Adult Walking Behavior
Protein Transport
Protein Ubiquitination
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Toll-like Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Follicle-stimulating Hormone Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Cell Chemotaxis
Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of DNA Biosynthetic Process
Pathways
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
HIV Infection
Host Interactions of HIV factors
Golgi Associated Vesicle Biogenesis
The role of Nef in HIV-1 replication and disease pathogenesis
Nef mediated downregulation of MHC class I complex cell surface expression
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
MHC class II antigen presentation
trans-Golgi Network Vesicle Budding
Adaptive Immune System
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
Signaling by Wnt
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Activated NOTCH1 Transmits Signal to the Nucleus
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Hedgehog 'on' state
Signaling by NOTCH1
WNT5A-dependent internalization of FZD4
Signaling by Hedgehog
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Platelet activation, signaling and aggregation
PCP/CE pathway
Activation of SMO
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Protein-Protein Interactions
22 interactors:
AMPH
AP1G1
AP1M1
AP1M2
ARF1
ARF5
ARF6
ARRB2
ATF7IP
ATM
ATR
BARD1
BUB1
BUB1B
CLTC
CREBBP
KIF13A
NTRK2
PIP5K1C
PRKDC
SHBG
SMAD2
47 interactors:
ADRB2
AGTR1
AP1B1
AP2M1
ARF6
AVPR2
C5AR1
CDC42
CLTC
CSNK2A1
CSNK2A2
CXCR4
CYTH2
DVL2
FLNA
FZD4
HCRTR1
HIPK3
HTR2C
ITCH
LHCGR
LIMK1
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK9
MDM2
MED8
NDUFS7
NFKBIA
NTS
NTSR1
OPRD1
OXTR
PARK2
PDE4D
PTAFR
PTGDS
RAF1
RALGDS
SLC9A5
SMARCC2
STC2
TGFBR3
TRH
USP33
Entrez ID
162
409
HPRD ID
02541
00147
Ensembl ID
ENSG00000100280
ENSG00000141480
Uniprot IDs
Q10567
K7ENA6
P32121
Q59EM5
PDB IDs
4HMY
Enriched GO Terms of Interacting Partners
?
Post-Golgi Vesicle-mediated Transport
Regulation Of Defense Response To Virus By Virus
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Protein Localization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Organelle Organization
Golgi Vesicle Transport
Protein Transport
Establishment Of Protein Localization
Cellular Localization
Viral Process
Regulation Of Defense Response To Virus
Establishment Of Vesicle Localization
Melanosome Organization
Pigment Granule Organization
Vesicle Localization
Cell Cycle
Cell Cycle Checkpoint
Antigen Processing And Presentation Of Peptide Antigen
Cell Cycle Process
Regulation Of Cellular Response To Heat
Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Mitotic Spindle Assembly Checkpoint
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Antigen Processing And Presentation
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Chromosome Segregation
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Establishment Of Organelle Localization
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Cell Differentiation
Regulation Of Mitotic Metaphase/anaphase Transition
Mitotic Cell Cycle Checkpoint
Negative Regulation Of Proteolysis
Cellular Protein Localization
Response To Gamma Radiation
Negative Regulation Of Protein Processing
Cellular Pigmentation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Temperature Stimulus
Endosome To Melanosome Transport
Pigment Granule Maturation
Regulation Of Protein Processing
Negative Regulation Of Proteasomal Protein Catabolic Process
Cell Surface Receptor Signaling Pathway
Cell Communication
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Signaling
Signal Transduction
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Response To External Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Stress-activated MAPK Cascade
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Organic Substance
Response To Stimulus
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of JNK Cascade
Response To Organic Substance
Positive Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Chemotaxis
Positive Regulation Of Protein Modification Process
Regulation Of Catalytic Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Phosphorylation
Locomotion
Immune System Process
Regulation Of Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
Regulation Of Kinase Activity
Fc Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Apoptotic Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Programmed Cell Death
Regulation Of MAP Kinase Activity
Response To Lipid
Tagcloud
?
17p13
22q11
adrbk2
adrenergic
ark
ark1
ark2
arrestin
assignment
band
chromosome
coding
cofactor
coupled
desensitization
grk4
grk5
grk6
includes
it11
mapped
mapping
multigene
occupied
phosphorylates
q37
refine
rhodopsin
sag
Tagcloud (Difference)
?
17p13
22q11
adrbk2
adrenergic
ark
ark1
ark2
arrestin
assignment
band
chromosome
coding
cofactor
coupled
desensitization
grk4
grk5
grk6
includes
it11
mapped
mapping
multigene
occupied
phosphorylates
q37
refine
rhodopsin
sag
Tagcloud (Intersection)
?