AP1B1 and AMPH

Number of citations of the paper that reports this interaction (PMID 9280305)
18

Data Source:
BioGRID (pull down)

		AP1B1	AMPH
Gene Name		adaptor-related protein complex 1, beta 1 subunit	amphiphysin
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane	Synaptic Vesicle Actin Cytoskeleton Cell Junction Synaptic Vesicle Membrane Leading Edge Membrane
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Protein Kinase Binding	Protein Binding Phospholipid Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization	Endocytosis Synaptic Transmission Learning Synaptic Vesicle Endocytosis
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		22 interactors: AMPH AP1G1 AP1M1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CLTC CREBBP KIF13A NTRK2 PIP5K1C PRKDC SHBG SMAD2	27 interactors: AP1B1 AP2A1 AP2A2 ARL16 BIN1 CABIN1 CCDC67 CDK1 CDK5 CDK5R1 CLTC DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 NECAP1 PLD2 PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		162	273
HPRD ID		02541	02687
Ensembl ID		ENSG00000100280	ENSG00000078053
Uniprot IDs		Q10567	P49418
PDB IDs		4HMY	1KY7 1UTC 3SOG 4ATM
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Regulation Of Defense Response To Virus By Virus Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Cellular Localization Viral Process Regulation Of Defense Response To Virus Establishment Of Vesicle Localization Melanosome Organization Pigment Granule Organization Vesicle Localization Cell Cycle Cell Cycle Checkpoint Antigen Processing And Presentation Of Peptide Antigen Cell Cycle Process Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Establishment Of Localization In Cell Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Antigen Processing And Presentation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Cell Cycle Phase Transition Establishment Of Organelle Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Cell Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Checkpoint Negative Regulation Of Proteolysis Cellular Protein Localization Response To Gamma Radiation Negative Regulation Of Protein Processing Cellular Pigmentation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Temperature Stimulus Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Protein Processing Negative Regulation Of Proteasomal Protein Catabolic Process	Endocytosis Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Receptor Metabolic Process Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Recycling Receptor-mediated Endocytosis Synaptic Vesicle Transport Receptor Internalization Regulation Of Signaling Synaptic Transmission Axon Guidance Peptidyl-threonine Phosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Neuron Projection Development Axon Development Regulation Of Signal Transduction Cell Projection Morphogenesis Establishment Of Vesicle Localization Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Positive Regulation Of Programmed Cell Death Cell Part Morphogenesis Chemotaxis Vesicle Localization Regulation Of Cellular Component Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Localization Positive Regulation Of Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Cycle Arrest Neurotrophin Signaling Pathway Establishment Of Localization In Cell
Tagcloud ?			10a 10as 6b 6br 7h amphetamine antipsychotic butan cataleptogenic demonstrable dimethoxy headtwitch hexahydro histaminergic ht2a ht2c hydrochloride hyperlocomotion id50 iodoamphetamine mesocortical mesolimbic microdialysis neurotransmission pyrido pyrrolo quinoxalin sert unwanted
Tagcloud (Difference) ?			10a 10as 6b 6br 7h amphetamine antipsychotic butan cataleptogenic demonstrable dimethoxy headtwitch hexahydro histaminergic ht2a ht2c hydrochloride hyperlocomotion id50 iodoamphetamine mesocortical mesolimbic microdialysis neurotransmission pyrido pyrrolo quinoxalin sert unwanted
Tagcloud (Intersection) ?