DAG1 and LAMA2

Number of citations of the paper that reports this interaction (PMID 7925941)
30

Data Source:
HPRD (in vivo, in vitro)

		DAG1	LAMA2
Gene Name		dystroglycan 1 (dystrophin-associated glycoprotein 1)	laminin, alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cell Outer Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Node Of Ranvier Sarcolemma Costamere Membrane Raft Postsynaptic Membrane Extracellular Vesicular Exosome Contractile Ring	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Matrix Sarcolemma Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding Protein Complex Binding SH2 Domain Binding Laminin-1 Binding Alpha-actinin Binding	Receptor Binding Structural Molecule Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis NLS-bearing Protein Import Into Nucleus Cytoskeletal Anchoring At Plasma Membrane Response To Virus Calcium-dependent Cell-matrix Adhesion Modulation By Virus Of Host Morphology Or Physiology Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of MAPK Cascade Response To Peptide Hormone Negative Regulation Of Protein Kinase B Signaling Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Commissural Neuron Axon Guidance Basement Membrane Organization	Cell Adhesion Axon Guidance Muscle Organ Development Myelination In Peripheral Nervous System Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Embryonic Development
Pathways		ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions	Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Body mass index ( 20397748) Refractive error ( 23396134)
Protein-Protein Interactions		25 interactors: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2	2 interactors: DAG1 RPSA
Entrez ID		1605	3908
HPRD ID		00546	01125
Ensembl ID		ENSG00000173402	ENSG00000196569
Uniprot IDs		Q14118	P24043 Q59H37
PDB IDs		1EG4
Enriched GO Terms of Interacting Partners?		Locomotion Regulation Of Cell Adhesion Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Axonogenesis Axon Development Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis System Development Neuron Projection Morphogenesis Cell Projection Organization Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Multicellular Organismal Development Positive Regulation Of Cell Adhesion Neuron Projection Development Anatomical Structure Development Cell Development Chemotaxis Negative Regulation Of Peptidyl-serine Phosphorylation Neuron Development Receptor Metabolic Process Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Neuron Differentiation Regulation Of Body Fluid Levels Nervous System Development Leukocyte Migration Wound Healing Cell Adhesion Cell Differentiation Generation Of Neurons Blood Coagulation Hemostasis Neurogenesis Regulation Of Phosphorylation Regulation Of Ion Transmembrane Transporter Activity Response To Wounding Muscle Organ Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Anoikis Muscle Structure Development Regulation Of Sodium Ion Transport Regulation Of Protein Phosphorylation Regulation Of Anoikis Regulation Of Phosphorus Metabolic Process Cytoskeleton Organization	Viral Life Cycle Nerve Maturation Nucleocytoplasmic Transport Nuclear Transport Calcium-dependent Cell-matrix Adhesion RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Establishment Of Protein Localization To Organelle Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Protein Targeting RRNA Transport RRNA 3'-end Processing Protein Localization To Organelle Viral Process Commissural Neuron Axon Guidance Cytoplasmic Transport Ribosomal Small Subunit Assembly Cytoskeletal Anchoring At Plasma Membrane Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Basement Membrane Organization Maturation Of 5.8S RRNA Intracellular Protein Transport Membrane Protein Ectodomain Proteolysis NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Morphology Or Physiology Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Branching Involved In Salivary Gland Morphogenesis Ribosome Assembly Maturation Of SSU-rRNA Cell Adhesion Membrane Protein Proteolysis Negative Regulation Of Protein Kinase B Signaling Cellular Protein Localization Ribosomal Small Subunit Biogenesis Salivary Gland Morphogenesis Viral Entry Into Host Cell Myelination In Peripheral Nervous System Salivary Gland Development Epithelial Tube Branching Involved In Lung Morphogenesis Protein Transport Entry Into Host Cell Schwann Cell Development Establishment Of Protein Localization Intracellular Transport Exocrine System Development Morphogenesis Of An Epithelial Sheet Microtubule Anchoring Schwann Cell Differentiation Lung Morphogenesis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Tagcloud ?		branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected	activlim ambulatory cmd cmds col6 dystrophy egen extremities fvc goniometry hammersmith hfms klassification meter mfm32 muscular myometry neuromuscular nsaa pedsql promis quest rater rd reliabilities sitting star timed walk
Tagcloud (Difference) ?		branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected	activlim ambulatory cmd cmds col6 dystrophy egen extremities fvc goniometry hammersmith hfms klassification meter mfm32 muscular myometry neuromuscular nsaa pedsql promis quest rater rd reliabilities sitting star timed walk
Tagcloud (Intersection) ?