SGOL1 and CDCA8

Number of citations of the paper that reports this interaction (PMID 20739936)
36

Data Source:
BioGRID (two hybrid)

		SGOL1	CDCA8
Gene Name		shugoshin-like 1 (S. pombe)	cell division cycle associated 8
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Spindle Pole Nucleoplasm Cytoplasm Centrosome Cytosol Mitotic Cohesin Complex	Chromosome, Centromeric Region Nucleus Nucleolus Spindle Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein Complex Intercellular Bridge
	Molecular Function	Protein Binding Kinase Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division	Mitotic Cell Cycle Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		21 interactors: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET UBC XRCC5 XRCC6	14 interactors: AURKB BIRC5 HIST2H3C HLA-DRB3 INCENP MAPKAPK5 NEK3 RANBP2 SGOL1 SGOL2 SUMO1 SUMO2 TTK UBE2I
Entrez ID		151648	55143
HPRD ID		12377	13017
Ensembl ID		ENSG00000129810	ENSG00000134690
Uniprot IDs		B5BUA4 Q5FBB7	Q53HL2
PDB IDs		3FGA 3Q6S 4A0I	2KDD 2QFA 2RAW 2RAX
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Viral Life Cycle Viral Transcription Protein Complex Disassembly SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Catabolic Process Aromatic Compound Catabolic Process Protein Localization To Endoplasmic Reticulum Translational Termination MRNA Metabolic Process Protein Targeting To Membrane Membrane Organization Translational Elongation Cellular Protein Complex Disassembly Positive Regulation Of Type I Interferon Production Double-strand Break Repair Via Nonhomologous End Joining Cellular Hyperosmotic Salinity Response Establishment Of Protein Localization To Membrane Translational Initiation Mitotic Cell Cycle Regulation Of Type I Interferon Production Cellular Response To X-ray Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Establishment Of Protein Localization To Organelle Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Membrane Programmed Cell Death Mitotic Cell Cycle Process Cell Death Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cytoplasmic Transport Cellular Response To Stress Establishment Of Integrated Proviral Latency Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Fibroblast Growth Factor Cellular Hyperosmotic Response Hyperosmotic Salinity Response Protein Targeting	Chromosome Segregation Mitotic Cell Cycle Cell Cycle Process Protein Sumoylation Mitotic Cell Cycle Process Cell Division Cell Cycle Mitotic Nuclear Division Organelle Organization Spindle Checkpoint Mitotic Spindle Organization Peptidyl-amino Acid Modification Peptidyl-lysine Modification Cellular Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Protein Modification By Small Protein Conjugation Cytokinesis Spindle Organization Mitotic Spindle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Microtubule Cytoskeleton Organization Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Division Regulation Of Proteolysis Microtubule Anchoring Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of SUMO Transferase Activity Protein Phosphorylation Negative Regulation Of Gene Expression Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule-based Process Meiotic Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Protein Metabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Protein Catabolic Process Negative Regulation Of Binding Histone H3-S28 Phosphorylation
Tagcloud ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated	allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated	allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?