NRG4 and ERBB4

Number of citations of the paper that reports this interaction (PMID 10348342)
29

Data Source:
HPRD (in vitro)

		NRG4	ERBB4
Gene Name		neuregulin 4	erb-b2 receptor tyrosine kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Growth Factor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Organ Development	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517) Urate levels ( 23263486)	Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		2 interactors: ERBB4 FATE1	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		145957	2066
HPRD ID		14871	02767
Ensembl ID			ENSG00000178568
Uniprot IDs		Q8WWG1	Q15303
PDB IDs			2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Regeneration Central Nervous System Morphogenesis Positive Regulation Of STAT Protein Import Into Nucleus Mitochondrial Fragmentation Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Mammary Gland Epithelial Cell Differentiation Mitochondrial Fission Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Heart Growth Olfactory Bulb Development Olfactory Lobe Development Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Organ Growth Neural Crest Cell Migration Regulation Of Phosphatidylinositol 3-kinase Activity Tissue Regeneration Lactation Regulation Of Heart Growth Regulation Of Lipid Kinase Activity Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of JAK-STAT Cascade Forebrain Neuron Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Neural Crest Cell Development Apoptotic Mitochondrial Changes Forebrain Generation Of Neurons Neural Crest Cell Differentiation Embryonic Pattern Specification Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Mammary Gland Epithelium Development Regulation Of Organ Growth Body Fluid Secretion Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Mesenchymal Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Striated Muscle Tissue Development Mesenchymal Cell Differentiation Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		activating adjacent alternatively deaths downregulated downregulation egfr epidermal gastric her2 her3 her4 immunohistochemistry interesting interestingly isoforms ligands matched oncogenes paired played qpcr quantified spliced splicing tissue unchanged undergoing upregulated	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		activating adjacent alternatively deaths downregulated downregulation egfr epidermal gastric her2 her3 immunohistochemistry interesting interestingly ligands matched oncogenes paired played qpcr quantified spliced splicing tissue unchanged undergoing upregulated	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin heregulin intrinsic ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?		her4 isoforms