NRG4

Gene Name		neuregulin 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Growth Factor Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Organ Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-protein Interactions		2 interactors: ERBB4 FATE1
Entrez ID		145957
HPRD ID		14871
Ensembl ID
Uniprot IDs		Q8WWG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Regeneration Central Nervous System Morphogenesis Positive Regulation Of STAT Protein Import Into Nucleus Mitochondrial Fragmentation Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Mammary Gland Epithelial Cell Differentiation Mitochondrial Fission Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Heart Growth Olfactory Bulb Development Olfactory Lobe Development Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Organ Growth Neural Crest Cell Migration Regulation Of Phosphatidylinositol 3-kinase Activity Tissue Regeneration Lactation Regulation Of Heart Growth Regulation Of Lipid Kinase Activity Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of JAK-STAT Cascade Forebrain Neuron Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Neural Crest Cell Development Apoptotic Mitochondrial Changes Forebrain Generation Of Neurons Neural Crest Cell Differentiation Embryonic Pattern Specification Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Mammary Gland Epithelium Development Regulation Of Organ Growth Body Fluid Secretion Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Mesenchymal Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Striated Muscle Tissue Development Mesenchymal Cell Differentiation Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		activating adjacent alternatively deaths downregulated downregulation egfr epidermal gastric her2 her3 her4 immunohistochemistry interesting interestingly isoforms ligands matched oncogenes paired played qpcr quantified spliced splicing tissue unchanged undergoing upregulated