ERBB4 and ADAM17

Number of citations of the paper that reports this interaction (PMID 15534001)
76

Data Source:
HPRD (in vitro)

		ERBB4	ADAM17
Gene Name		erb-b2 receptor tyrosine kinase 4	ADAM metallopeptidase domain 17
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Lipopolysaccharide Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Response To Drug Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Spleen Development Cell Motility PMA-inducible Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cellular Component Movement Response To High Density Lipoprotein Particle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Hedgehog ligand biogenesis TNF signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Death Receptor Signalling Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Release of Hh-Np from the secreting cell Signaling by NOTCH1 Programmed Cell Death Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Regulated proteolysis of p75NTR Signalling by NGF Collagen degradation Signaling by NOTCH Processing-defective Hh variants abrogate ligand secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 Signaling by EGFR in Cancer Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Extrinsic Pathway Growth hormone receptor signaling
Drugs
Diseases
GWAS		Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1	14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11
Entrez ID		2066	6868
HPRD ID		02767	04703
Ensembl ID		ENSG00000178568	ENSG00000151694
Uniprot IDs		Q15303	B2RNB2 P78536
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U	1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gland Development Positive Regulation Of Phosphorylation Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Response To Tumor Necrosis Factor Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of APC-Cdc20 Complex Activity Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Cell Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Fever Generation Activation Of Protein Kinase Activity
Tagcloud ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Difference) ?		180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally
Tagcloud (Intersection) ?		transmembrane