CRP and HIST1H2AL

Number of citations of the paper that reports this interaction (PMID 1989977)
15

Data Source:
HPRD (in vitro, in vivo)

		CRP	HIST1H2AL
Gene Name		C-reactive protein, pentraxin-related	histone cluster 1, H2al
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Filopodium Growth Cone Extracellular Vesicular Exosome	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Cholesterol Binding Low-density Lipoprotein Particle Binding Choline Binding Protein Homodimerization Activity Virion Binding Low-density Lipoprotein Particle Receptor Binding	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Aging Opsonization Response To Lead Ion Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Wound Healing Response To Ethanol Negative Regulation Of Vasodilation Defense Response To Gram-positive Bacterium Protein Polymerization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Development Regulation Of Interleukin-8 Secretion	Biological_process
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HATs acetylate histones RMTs methylate histone arginines
Drugs		Phosphocholine
Diseases
GWAS		C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 21300955 22939635) Inflammatory biomarkers ( 22291609) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Protein-Protein Interactions		20 interactors: APCS C1QA CFH DGCR14 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 HIST1H1A HIST1H2AL HIST2H2AC LAMC3 LEP MAPK1 MAPK3 RPL13A SNRNP70	5 interactors: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		1401	8332
HPRD ID		00422	09103
Ensembl ID		ENSG00000132693	ENSG00000198374
Uniprot IDs		P02741	A4FTV9 P0C0S8
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?		Immune System Process Innate Immune Response Immune Response Regulation Of Immune System Process Defense Response Regulation Of Golgi Inheritance Regulation Of Immune Response Positive Regulation Of Immune System Process Caveolin-mediated Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response JAK-STAT Cascade Regulation Of Golgi Organization Platelet Activation Response To Stress Regulation Of Early Endosome To Late Endosome Transport Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Cytokine Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Blood Coagulation Hemostasis Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Immune Response-regulating Signaling Pathway Response To Growth Hormone Response To Exogenous DsRNA Leukocyte Migration Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Apolipoprotein Binding Cellular Response To L-ascorbic Acid Toll-like Receptor 5 Signaling Pathway Viral Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Toll-like Receptor 9 Signaling Pathway	Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cellular Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Chromosome Organization Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Vasodilation Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Superoxide Anion Generation Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Opsonization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of P38MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Lipid Storage Regulation Of Telomere Maintenance RNA-dependent DNA Replication Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Negative Regulation Of DNA Recombination Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Response To Lead Ion Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Acute-phase Response Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasodilation Regulation Of Histone Acetylation Cellular Response To Calcium Ion Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Difference) ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Intersection) ?