CRP and HIST1H1A

Number of citations of the paper that reports this interaction (PMID 1989977)
15

Data Source:
HPRD (in vivo)

		CRP	HIST1H1A
Gene Name		C-reactive protein, pentraxin-related	histone cluster 1, H1a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Filopodium Growth Cone Extracellular Vesicular Exosome	Nucleosome Nuclear Chromatin Nuclear Euchromatin
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Cholesterol Binding Low-density Lipoprotein Particle Binding Choline Binding Protein Homodimerization Activity Virion Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Chromatin DNA Binding
	Biological Process	Response To Hypoxia Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Aging Opsonization Response To Lead Ion Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Wound Healing Response To Ethanol Negative Regulation Of Vasodilation Defense Response To Gram-positive Bacterium Protein Polymerization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Development Regulation Of Interleukin-8 Secretion	Nucleosome Assembly Spermatogenesis
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs		Phosphocholine
Diseases
GWAS		C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 21300955 22939635) Inflammatory biomarkers ( 22291609) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Protein-Protein Interactions		20 interactors: APCS C1QA CFH DGCR14 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 HIST1H1A HIST1H2AL HIST2H2AC LAMC3 LEP MAPK1 MAPK3 RPL13A SNRNP70	45 interactors: AEBP2 CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP PARP1 PARP3 PELP1 PKN1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 SUZ12 TERF1 TERF2IP TLK1 WHSC1L1
Entrez ID		1401	3024
HPRD ID		00422	00820
Ensembl ID		ENSG00000132693	ENSG00000124610
Uniprot IDs		P02741	Q02539
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?		Immune System Process Innate Immune Response Immune Response Regulation Of Immune System Process Defense Response Regulation Of Golgi Inheritance Regulation Of Immune Response Positive Regulation Of Immune System Process Caveolin-mediated Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response JAK-STAT Cascade Regulation Of Golgi Organization Platelet Activation Response To Stress Regulation Of Early Endosome To Late Endosome Transport Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Cytokine Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Blood Coagulation Hemostasis Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Immune Response-regulating Signaling Pathway Response To Growth Hormone Response To Exogenous DsRNA Leukocyte Migration Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Apolipoprotein Binding Cellular Response To L-ascorbic Acid Toll-like Receptor 5 Signaling Pathway Viral Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Toll-like Receptor 9 Signaling Pathway	Chromosome Organization Cell Cycle Chromatin Organization Chromatin Modification Regulation Of Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Histone Modification Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle DNA Metabolic Process Cellular Response To Stress Response To Stress Histone Phosphorylation Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Cellular Metabolic Process Regulation Of Cell Cycle Process Phosphorylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic
Tagcloud ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Difference) ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Intersection) ?