CRP and RPL13A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRP	RPL13A
Gene Name		C-reactive protein, pentraxin-related	ribosomal protein L13a
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Filopodium Growth Cone Extracellular Vesicular Exosome	Nucleus Cytosol Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex GAIT Complex
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Cholesterol Binding Low-density Lipoprotein Particle Binding Choline Binding Protein Homodimerization Activity Virion Binding Low-density Lipoprotein Particle Receptor Binding	Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Aging Opsonization Response To Lead Ion Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Wound Healing Response To Ethanol Negative Regulation Of Vasodilation Defense Response To Gram-positive Bacterium Protein Polymerization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Development Regulation Of Interleukin-8 Secretion	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Negative Regulation Of Translation Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Cellular Response To Interferon-gamma Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		Phosphocholine
Diseases
GWAS		C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 21300955 22939635) Inflammatory biomarkers ( 22291609) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)	Hematological and biochemical traits ( 20139978)
Protein-Protein Interactions		20 interactors: APCS C1QA CFH DGCR14 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 HIST1H1A HIST1H2AL HIST2H2AC LAMC3 LEP MAPK1 MAPK3 RPL13A SNRNP70	13 interactors: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBXO18 FNTA GOLM1 ND1 RPL30 STOM VTN
Entrez ID		1401	23521
HPRD ID		00422	11775
Ensembl ID		ENSG00000132693	ENSG00000142541
Uniprot IDs		P02741	P40429 Q8J015
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO	3J3B
Enriched GO Terms of Interacting Partners?		Immune System Process Innate Immune Response Immune Response Regulation Of Immune System Process Defense Response Regulation Of Golgi Inheritance Regulation Of Immune Response Positive Regulation Of Immune System Process Caveolin-mediated Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response JAK-STAT Cascade Regulation Of Golgi Organization Platelet Activation Response To Stress Regulation Of Early Endosome To Late Endosome Transport Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Cytokine Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Blood Coagulation Hemostasis Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Immune Response-regulating Signaling Pathway Response To Growth Hormone Response To Exogenous DsRNA Leukocyte Migration Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Apolipoprotein Binding Cellular Response To L-ascorbic Acid Toll-like Receptor 5 Signaling Pathway Viral Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Toll-like Receptor 9 Signaling Pathway	Regulation Of Rhodopsin Mediated Signaling Pathway Response To Inorganic Substance Rhodopsin Mediated Signaling Pathway Positive Regulation Of Tubulin Deacetylation Regulation Of Acid-sensing Ion Channel Activity Regulation Of Cation Channel Activity Phototransduction, Visible Light Detection Of Visible Light Positive Regulation Of Protein Modification Process Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Cellular Metabolic Process Detection Of Light Stimulus Catabolic Process Response To Calcium Ion Nucleus Organization Response To Intra-S DNA Damage Checkpoint Signaling Protein Farnesylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Radiation Response To Ethanol Regulation Of Tubulin Deacetylation PML Body Organization Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Xenobiotic Stimulus Positive Regulation Of Deacetylase Activity Monoterpenoid Metabolic Process Response To Ozone Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Protein Metabolic Process Synaptic Transmission Wound Healing Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Immune Response Regulation Of Immune System Process Negative Regulation Of Vasodilation Neurotransmitter Receptor Metabolic Process Protein Geranylgeranylation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ethanol Catabolic Process Response To Reactive Oxygen Species Positive Regulation Of Superoxide Anion Generation
Tagcloud ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral	aleyrodidae bemisia bestkeeper cyclophilin cyp1 developmentally ef1a gapdh gennadius genorm glyceraldehyde hemiptera normalisation normfinder orthologs qpcr realtime selecting sented suitability tabaci thermal transcript tub1a utilising vitellogenin whiteflies whitefly
Tagcloud (Difference) ?		antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral	aleyrodidae bemisia bestkeeper cyclophilin cyp1 developmentally ef1a gapdh gennadius genorm glyceraldehyde hemiptera normalisation normfinder orthologs qpcr realtime selecting sented suitability tabaci thermal transcript tub1a utilising vitellogenin whiteflies whitefly
Tagcloud (Intersection) ?