CPT1A and HSPA5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CPT1A	HSPA5
Gene Name		carnitine palmitoyltransferase 1A (liver)	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Integral Component Of Mitochondrial Outer Membrane	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Carnitine O-palmitoyltransferase Activity Identical Protein Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Fatty Acid	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) RORA activates circadian gene expression	Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs		L-Carnitine Perhexiline	Antihemophilic Factor
Diseases
GWAS		Lipid metabolism phenotypes ( 22286219) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		1374	3309
HPRD ID		02755	00682
Ensembl ID		ENSG00000110090	ENSG00000044574
Uniprot IDs		B2RAQ8 P50416 Q8WZ48	P11021
PDB IDs		2LE3	3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucose Starvation Regulation Of Mitochondrial Membrane Potential Response To Gamma Radiation Neural Nucleus Development Positive Regulation Of Endothelial Cell Proliferation Response To Nutrient Levels Response To Extracellular Stimulus Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Endothelial Cell Proliferation Renal System Process Negative Regulation Of Cellular PH Reduction Smooth Muscle Hypertrophy CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Regulation Of Ion Transport Response To Stress Positive Regulation Of Cell Growth Metencephalon Development Cell Activation Response To External Stimulus Response To Wounding Cerebellum Structural Organization Response To Cytokine Cellular Response To Starvation Cellular Response To Organic Substance Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Regulation Of Renal Output By Angiotensin Positive Regulation Of Cell Proliferation Hindbrain Development Response To Toxic Substance Cellular Response To Nutrient Levels Response To Starvation Response To Organic Cyclic Compound Cochlear Nucleus Development Regulation Of Nitrogen Utilization Regulation Of Calcium Ion Transport Platelet Activation Intracellular Receptor Signaling Pathway Regulation Of Ossification Negative Regulation Of Apoptotic Process	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?