CPN2 and CPN1

Number of citations of the paper that reports this interaction (PMID 14687935)
17

Data Source:
HPRD (in vitro)

		CPN2	CPN1
Gene Name		carboxypeptidase N, polypeptide 2	carboxypeptidase N, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space
	Molecular Function	Enzyme Regulator Activity	Metallocarboxypeptidase Activity Zinc Ion Binding
	Biological Process	Regulation Of Catalytic Activity Protein Stabilization	Proteolysis Bradykinin Catabolic Process Response To Glucocorticoid
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757)
Protein-Protein Interactions		1 interactors: CPN1	6 interactors: C3 C5 CDC42 CLEC4G CPN2 KNG1
Entrez ID		1370	1369
HPRD ID		11928	09120
Ensembl ID		ENSG00000178772	ENSG00000120054
Uniprot IDs		P22792	B1AP59 P15169
PDB IDs			2NSM
Enriched GO Terms of Interacting Partners?		Bradykinin Catabolic Process Peptide Catabolic Process Peptide Metabolic Process Response To Glucocorticoid Response To Corticosteroid	Complement Activation, Alternative Pathway Protein Activation Cascade Positive Regulation Of Transport Regulation Of Catalytic Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Complement Activation Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endopeptidase Activity Regulation Of Humoral Immune Response Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Defense Response Regulation Of Peptidase Activity Inflammatory Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune Response Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Angiogenesis Complement Activation, Classical Pathway Regulation Of Protein Stability Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Complement Activation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Protein Phosphorylation Regulation Of Angiogenesis Leukocyte Migration
Tagcloud ?		4g attaching bisect capped corresponded cpc cpc2 cpc3 directing eif3 eif4a eif4e eif4g formerly helicase judged m7gtp p220 picornaviral picornaviruses proteases proteolysis recruiting rhinovirus sedimentation separates sepharose ultracentrifugal	accumulates bimolecular catalyses complementation copine crystallinum cytoskeleton fermenting halophyte imbalanced interacted ka1 links mccpn1 mcskd1 mcsnrk1 mesembryanthemum myristoylation phosphorylate physically relate salt skd1 snrk1 stkc sucrose ternary uba ubiquitination
Tagcloud (Difference) ?		4g attaching bisect capped corresponded cpc cpc2 cpc3 directing eif3 eif4a eif4e eif4g formerly helicase judged m7gtp p220 picornaviral picornaviruses proteases proteolysis recruiting rhinovirus sedimentation separates sepharose ultracentrifugal	accumulates bimolecular catalyses complementation copine crystallinum cytoskeleton fermenting halophyte imbalanced interacted ka1 links mccpn1 mcskd1 mcsnrk1 mesembryanthemum myristoylation phosphorylate physically relate salt skd1 snrk1 stkc sucrose ternary uba ubiquitination
Tagcloud (Intersection) ?