CPN1 and CPN2

Number of citations of the paper that reports this interaction (PMID 14687935)
17

Data Source:
HPRD (in vitro)

		CPN1	CPN2
Gene Name		carboxypeptidase N, polypeptide 1	carboxypeptidase N, polypeptide 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Enzyme Regulator Activity
	Biological Process	Proteolysis Bradykinin Catabolic Process Response To Glucocorticoid	Regulation Of Catalytic Activity Protein Stabilization
Pathways		Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757)
Protein-Protein Interactions		6 interactors: C3 C5 CDC42 CLEC4G CPN2 KNG1	1 interactors: CPN1
Entrez ID		1369	1370
HPRD ID		09120	11928
Ensembl ID		ENSG00000120054	ENSG00000178772
Uniprot IDs		B1AP59 P15169	P22792
PDB IDs		2NSM
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Protein Activation Cascade Positive Regulation Of Transport Regulation Of Catalytic Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Complement Activation Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endopeptidase Activity Regulation Of Humoral Immune Response Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Defense Response Regulation Of Peptidase Activity Inflammatory Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune Response Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Angiogenesis Complement Activation, Classical Pathway Regulation Of Protein Stability Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Complement Activation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Protein Phosphorylation Regulation Of Angiogenesis Leukocyte Migration	Bradykinin Catabolic Process Peptide Catabolic Process Peptide Metabolic Process Response To Glucocorticoid Response To Corticosteroid
Tagcloud ?		accumulates bimolecular catalyses complementation copine crystallinum cytoskeleton fermenting halophyte imbalanced interacted ka1 links mccpn1 mcskd1 mcsnrk1 mesembryanthemum myristoylation phosphorylate physically relate salt skd1 snrk1 stkc sucrose ternary uba ubiquitination	4g attaching bisect capped corresponded cpc cpc2 cpc3 directing eif3 eif4a eif4e eif4g formerly helicase judged m7gtp p220 picornaviral picornaviruses proteases proteolysis recruiting rhinovirus sedimentation separates sepharose ultracentrifugal
Tagcloud (Difference) ?		accumulates bimolecular catalyses complementation copine crystallinum cytoskeleton fermenting halophyte imbalanced interacted ka1 links mccpn1 mcskd1 mcsnrk1 mesembryanthemum myristoylation phosphorylate physically relate salt skd1 snrk1 stkc sucrose ternary uba ubiquitination	4g attaching bisect capped corresponded cpc cpc2 cpc3 directing eif3 eif4a eif4e eif4g formerly helicase judged m7gtp p220 picornaviral picornaviruses proteases proteolysis recruiting rhinovirus sedimentation separates sepharose ultracentrifugal
Tagcloud (Intersection) ?