TRIM50 and UBE2E2

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM50	UBE2E2
Gene Name		tripartite motif containing 50	ubiquitin-conjugating enzyme E2E 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Metabolic Process	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		9 interactors: HDAC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N	61 interactors: APP ARIH1 ARIH2 ARRDC3 BARD1 BRCA1 CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B FHL1 IPO11 ISG15 MARCH3 MDM2 MID1 MID2 MKRN3 MUL1 NFE2L2 PCGF2 PRAM1 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1
Entrez ID		135892	7325
HPRD ID		15566	06779
Ensembl ID		ENSG00000146755
Uniprot IDs		B7ZLG2 Q2M204 Q86XT4	Q96LR5
PDB IDs			1Y6L
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process ISG15-protein Conjugation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Immune Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Negative Regulation Of Viral Process Protein Autoubiquitination Catabolic Process Regulation Of Viral Process Proteolysis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Negative Regulation Of Cellular Metabolic Process Histone H2A Ubiquitination Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Viral Transcription Response To Stress Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Cellular Response To Stress Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression
Tagcloud ?		acetylation acetyltransferases aggresome balance clearance critical deacetylase degradation dependent e3 formation hdac6 identified interaction ligase lys microtubule p300 pcaf polyubiquitinated promotes regulates report residue showed target tubulin ubiquitin ubiquitination	3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin
Tagcloud (Difference) ?		acetylation acetyltransferases aggresome balance clearance critical deacetylase degradation dependent e3 formation hdac6 identified interaction ligase lys microtubule p300 pcaf polyubiquitinated promotes regulates report residue showed target tubulin ubiquitination	3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2
Tagcloud (Intersection) ?		ubiquitin