TRIM50

Gene Name		tripartite motif containing 50
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Zinc Ion Binding Ligase Activity
	Biological Process	Metabolic Process
Pathways
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-protein Interactions		9 interactors: HDAC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N
Entrez ID		135892
HPRD ID		15566
Ensembl ID		ENSG00000146755
Uniprot IDs		B7ZLG2 Q2M204 Q86XT4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process ISG15-protein Conjugation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Immune Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint
Tagcloud ?		acetylation acetyltransferases aggresome balance clearance critical deacetylase degradation dependent e3 formation hdac6 identified interaction ligase lys microtubule p300 pcaf polyubiquitinated promotes regulates report residue showed target tubulin ubiquitin ubiquitination