UBE2E2 and TRIM31

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid)

		UBE2E2	TRIM31
Gene Name		ubiquitin-conjugating enzyme E2E 2	tripartite motif containing 31
Image
Gene Ontology Annotations	Cellular Component		Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding Ligase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Beta-2 microglubulin plasma levels ( 23417110)
Protein-Protein Interactions		61 interactors: APP ARIH1 ARIH2 ARRDC3 BARD1 BRCA1 CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B FHL1 IPO11 ISG15 MARCH3 MDM2 MID1 MID2 MKRN3 MUL1 NFE2L2 PCGF2 PRAM1 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1	17 interactors: IKBKG MAGEA1 MAGEA2B MKRN3 MNAT1 TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2W USP7 ZSCAN1
Entrez ID		7325	11074
HPRD ID		06779	10281
Ensembl ID			ENSG00000204616
Uniprot IDs		Q96LR5	Q2L6J1 Q9BZY9
PDB IDs		1Y6L	2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Negative Regulation Of Viral Process Protein Autoubiquitination Catabolic Process Regulation Of Viral Process Proteolysis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Negative Regulation Of Cellular Metabolic Process Histone H2A Ubiquitination Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Viral Transcription Response To Stress Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Cellular Response To Stress Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Cellular Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Response To Stress Protein Metabolic Process Cellular Metabolic Process Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Cellular Response To Oxygen Levels
Tagcloud ?		3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin	advanced aims biological bronchial colony corresponding cyclin downregulation h1299 h157 hbe immumohistochemistry lines lung metastasis might nodal nsclc overexpression pattern plasmid regulator roles serve small suppressor tissues tnm transfection
Tagcloud (Difference) ?		3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin	advanced aims biological bronchial colony corresponding cyclin downregulation h1299 h157 hbe immumohistochemistry lines lung metastasis might nodal nsclc overexpression pattern plasmid regulator roles serve small suppressor tissues tnm transfection
Tagcloud (Intersection) ?