CORT and SSTR5

Number of citations of the paper that reports this interaction (PMID 9205124)
10

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		CORT	SSTR5
Gene Name		cortistatin	somatostatin receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	G-protein Coupled Receptor Binding Neuropeptide Hormone Activity	Somatostatin Receptor Activity Neuropeptide Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Cell Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	8 interactors: ADCY10 CORT DRD2 GOPC PDZK1 PEX5 SST SSTR1
Entrez ID		1325	6755
HPRD ID		04150	01677
Ensembl ID		ENSG00000241563	ENSG00000162009
Uniprot IDs		O00230 Q8IUV6	P35346
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Estrogen Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Steroid Hormone Stimulus Response To Peptide G-protein Coupled Receptor Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Cell-cell Signaling Response To Estradiol Cellular Response To Organic Cyclic Compound Response To Hormone Cellular Response To Lipid Response To Glucocorticoid Response To Steroid Hormone Response To Corticosteroid Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Nutrient Levels Cerebellum Development Forebrain Development Response To Extracellular Stimulus Metencephalon Development Response To Organic Substance Hindbrain Development Response To Starvation Regulation Of Cell Proliferation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Signal Transduction Brain Development Head Development Multicellular Organismal Reproductive Process Regulation Of Hormone Secretion Signaling Multicellular Organism Reproduction	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Cerebral Cortex Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Cell-cell Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Forebrain Development G-protein Coupled Receptor Signaling Pathway Cytoplasmic Sequestering Of CFTR Protein Regulation Of Multicellular Organism Growth Telencephalon Cell Migration Forebrain Cell Migration Spermatogenesis Male Gamete Generation Response To Drug Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Homotetramerization Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Neuromuscular Process Monocarboxylic Acid Transport Regulation Of Protein Transport Hormone-mediated Signaling Pathway Regulation Of Anion Transport Regulation Of Locomotion Involved In Locomotory Behavior Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Dopamine Receptor Signaling Pathway Gamete Generation Positive Regulation Of Developmental Growth Negative Regulation Of Cell Proliferation Regulation Of Establishment Of Protein Localization Cytoplasmic Transport Negative Regulation Of Dopamine Secretion Protein Import Into Peroxisome Matrix, Docking Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Morphogenesis Of A Nerve Neuron Migration Negative Regulation Of Voltage-gated Calcium Channel Activity Orbitofrontal Cortex Development Somatostatin Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Protein Transport Brain Development Regulation Of Protein Localization Sexual Reproduction Head Development Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Homooligomerization Hormone-mediated Apoptotic Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway
Tagcloud ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?