CCR7 and CCL19

Number of citations of the paper that reports this interaction (PMID 9153236)
56

Data Source:
HPRD (in vivo, in vitro)

		CCR7	CCL19
Gene Name		chemokine (C-C motif) receptor 7	chemokine (C-C motif) ligand 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	G-protein Coupled Receptor Activity C-C Chemokine Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 19 Receptor Activity C-C Motif Chemokine 21 Receptor Activity	Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Establishment Of T Cell Polarity Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Hypersensitivity Positive Regulation Of Humoral Immune Response Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Ruffle Organization Response To Lipopolysaccharide Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Activation Of Rho GTPase Activity Response To Prostaglandin E Chemokine (C-C Motif) Ligand 19 Signaling Pathway Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Thymic T Cell Selection Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Into Lymph Node Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Immunological Synapse Formation Positive Regulation Of T Cell Costimulation Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Regulation Of Dendritic Cell Dendrite Assembly	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process T Cell Costimulation Positive Regulation Of Ras GTPase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Positive Regulation Of ERK1 And ERK2 Cascade Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CCL19 CCL21 CCR10	6 interactors: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13
Entrez ID		1236	6363
HPRD ID		02588	03750
Ensembl ID		ENSG00000126353	ENSG00000172724
Uniprot IDs		A0N0Q0 P32248	Q6IBD6 Q99731
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Dendritic Cell Dendrite Assembly Establishment Of T Cell Polarity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cytosolic Calcium Ion Homeostasis Dendritic Cell Chemotaxis Immunological Synapse Formation Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Response To Prostaglandin E Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Granulocyte Chemotaxis Cellular Ion Homeostasis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Sequestering Of Calcium Ion Metal Ion Homeostasis Leukocyte Activation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cellular Chemical Homeostasis Regulation Of Phosphatidylinositol 3-kinase Activity Ion Homeostasis Negative Regulation Of Leukocyte Apoptotic Process Chemotaxis Regulation Of Lipid Kinase Activity Cell-cell Recognition Positive Regulation Of Leukocyte Chemotaxis Cell Activation Cellular Homeostasis Response To Fatty Acid T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Leukocyte Migration Chemical Homeostasis Leukocyte Chemotaxis Positive Regulation Of Endocytosis Positive Regulation Of Chemotaxis Establishment Of Cell Polarity	Chemokine-mediated Signaling Pathway Chemotaxis Inflammatory Response Cytokine-mediated Signaling Pathway Locomotion Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Response To External Stimulus Immune System Process G-protein Coupled Receptor Signaling Pathway Defense Response Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Cytosolic Calcium Ion Homeostasis Neutrophil Activation Cellular Response To Organic Substance Lymphocyte Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Response To Organic Substance Activation Of Ras GTPase Activity Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Cation Homeostasis Signal Transduction Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Signaling Positive Regulation Of Leukocyte Migration Cell Communication Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Ion Homeostasis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Response To Stress
Tagcloud ?		capture ccr1 ccr2 ccr5 cd40 chemokine chemokines cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?		capture ccr1 ccr2 ccr5 cd40 cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?		chemokine chemokines